From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction

…, BK Vicknasingam, D Amato, S von Hörsten… - Neuroscience & …, 2013 - Elsevier
Kratom (or Ketum) is a psychoactive plant preparation used in Southeast Asia. It is derived
from the plant Mitragyna speciosa Korth. Kratom as well as its main alkaloid, mitragynine, …

Cut to the chase: a review of CD26/dipeptidyl peptidase-4's (DPP4) entanglement in the immune system

…, L Wagner, M Stephan, S von Hörsten - Clinical & …, 2016 - academic.oup.com
S von Hörsten S von HörstenSS bridges are illustrated in yellow and carbohydrates in
orange. Structures were drawn with PyMOLTM 2008 DeLano Scientific LLC, using Protein Data …

The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y

A Kask, J Harro, S von Hörsten, JP Redrobe… - Neuroscience & …, 2002 - Elsevier
This review aims to give a brief overview of NPY receptor distribution and physiology in the
brain and summarizes series of studies, test by test and region by region, aimed at …

Transgenic rat model of Huntington's disease

S von Hörsten, I Schmitt, HP Nguyen… - Human molecular …, 2003 - academic.oup.com
Huntington's disease (HD) is a late manifesting neurodegenerative disorder in humans
caused by an expansion of a CAG trinucleotide repeat of more than 39 units in a gene of …

Behavioral phenotyping of mice in pharmacological and toxicological research

T Karl, R Pabst, S von Hörsten - Experimental and Toxicologic Pathology, 2003 - Elsevier
The evaluation of behavioral effects is an important component for the in vivo screening of
drugs or potentially toxic compounds in mice. Ideally, such screening should be composed of …

Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease

…, B Winner, J Winkler, S von Hörsten… - Journal of …, 2008 - Soc Neuroscience
α-Synuclein (α-syn) has been implicated in the pathogenesis of many neurodegenerative
disorders, including Parkinson's disease. These disorders are characterized by various …

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate–Aβ formation

…, AP Osmand, HU Demuth, S von Hörsten - Journal of …, 2011 - Soc Neuroscience
Posttranslational amyloid-β (Aβ) modification is considered to play an important role in
Alzheimer's disease (AD) etiology. An N-terminally modified Aβ species, pyroglutamate-amyloid-β …

Inhibition of CD26/dipeptidyl peptidase IV enhances CCL11/eotaxin-mediated recruitment of eosinophils in vivo

…, WG Forssmann, J Elsner, S von Hörsten - The Journal of …, 2008 - journals.aai.org
Chemokines mediate the recruitment of leukocytes to the sites of inflammation. N-terminal
truncation of chemokines by the protease dipeptidyl peptidase IV (DPPIV) potentially restricts …

Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homologue (DASH) proteins

…, M Stephan, S Von Hörsten - Clinical & …, 2016 - academic.oup.com
S von Hörsten S von Hörsten … The long form DPL1-L is an 859 amino acid protein with a
molecular weight of 97 kDa, whereas the short form, DPL1-S, consists of 803 amino acids with a …

Sex differences in a transgenic rat model of Huntington's disease: decreased 17β-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males

…, C Sjoberg, Å Petersén, S von Hörsten - Human molecular …, 2008 - academic.oup.com
Recent clinical studies have highlighted that female sex hormones represent potential
neuroprotective mediators against damage caused by acute and chronic brain diseases. This …