Synaptic transmission is maintained by a delicate, sub-synaptic molecular architecture, and
even mild alterations in synapse structure drive functional changes during experience-…

Formation of mature excitatory synapses requires the assembly and delivery of NMDA
receptors to the neuronal plasma membrane. A key step in the trafficking of NMDA receptors to …

Endocytosis is a fundamental mechanism by which neurons control intercellular signaling,
nutrient uptake, and synaptic transmission. This process is carried out by the assembly of …

… We would like to thank Scott Thompson, John Lisman, and members of the Blanpied
Laboratory for helpful discussions and critical evaluation of the manuscript, Nick Frost for help …

Blanpied, Thomas A., Faye Boeckman, Elias Aizenman, and Jon W. Johnson. Trapping channel
block of NMDA-activated responses by amantadine and memantine. J. Neurophysiol. 77…

Endocytosis of AMPA receptors and other postsynaptic cargo occurs at endocytic zones (EZs),
stably positioned sites of clathrin adjacent to the postsynaptic density (PSD). The tight …

At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …

Within dendritic spines, actin is presumed to anchor receptors in the postsynaptic density
and play numerous roles regulating synaptic transmission. However, the submicron …

The channel of NMDA receptors is blocked by a wide variety of drugs. NMDA receptor channel
blockers include drugs of abuse that induce psychotic behavior, such as phencyclidine, …

Psychiatric and neurologic disorders ranging from mental retardation to addiction are
accompanied by structural and functional alterations of synaptic connections in the brain. Such …