User profiles for T. Benzinger

Tammie LS Benzinger, MD, PhD

Departments of Radiology and Neurosurgery, Washington University School of Medicine in …
Verified email at wustl.edu
Cited by 34114

Heat regulation: homeostasis of central temperature in man

TH Benzinger - Physiological reviews, 1969 - journals.physiology.org
Benzinger's conclusions are sweeping albeit drawn from elegant instrumentation. … T of the
air as it entered and left was ascertained by a saturator (SAT) operated at low temperature T

[HTML][HTML] PET amyloid-beta imaging in preclinical Alzheimer's disease

AG Vlassenko, TLS Benzinger, JC Morris - Biochimica et Biophysica Acta …, 2012 - Elsevier
Alzheimer's disease (AD) is the leading cause of dementia, accounting for 60–70% of all
cases [Hebert et al., 2003, 1]. The need for effective therapies for AD is great. Current …

[HTML][HTML] Clinical and biomarker changes in dominantly inherited Alzheimer's disease

RJ Bateman, C Xiong, TLS Benzinger… - … England Journal of …, 2012 - Mass Medical Soc
Background The order and magnitude of pathologic processes in Alzheimer's disease are
not well understood, partly because the disease develops over many years. Autosomal …

Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial

…, PS Aisen, MC Althage, S Belyew, TL Benzinger… - Revue …, 2013 - Elsevier
The Dominantly Inherited Alzheimer's Network Trials Unit (DIAN-TU) was formed to direct
the design and management of interventional therapeutic trials of international DIAN and …

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

…, DP Buennagel, MG Harrington, TLS Benzinger… - Nature, 2020 - nature.com
… Significance by ANCOVA for group comparisons controlling for age, sex, and education,
and two-tailed t-tests for comparison of PET values to standardized uptake value ratios (SUVR) …

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

…, DP Buennagel, MG Harrington, TLS Benzinger… - Nature medicine, 2019 - nature.com
… . Briefly, all images were obtained on a GE 3 T HDXT MR scanner with a standard eight-channel
array head coil. Anatomical coronal spin echo T2-weighted scans were first obtained …

Propagating structure of Alzheimer's β-amyloid(10–35) is parallel β-sheet with residues in exact register

TLS Benzinger, DM Gregory… - Proceedings of the …, 1998 - National Acad Sciences
… For S T equaling total experimentally observed signal, one obtains \[ \begin{equation*}S_{T}=aS_{L}+bS_{U}\end{equation*}\] …
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A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease

…, BA Gordon, J Hassenstab, TLS Benzinger… - Nature medicine, 2020 - nature.com
… In AD, soluble p-tau181 (pT181) and t-tau are elevated in the cerebrospinal fluid (CSF) 10,…
lobar degeneration-tau), CSF levels of soluble pT181 and t-tau do not increase 17,18 , and in …

[HTML][HTML] Hippocampal avoidance during whole-brain radiotherapy plus memantine for patients with brain metastases: phase III trial NRG oncology CC001

…, D Khuntia, D Grosshans, TLS Benzinger… - Journal of Clinical …, 2020 - ncbi.nlm.nih.gov
… and symptom items were compared between arms using a t test. Trends across time on the
… , with differences at 6 months tested using a t test. Individual MDASI-BT items were compared …

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease

…, AM Fagan, JC Morris, TLS Benzinger… - Science translational …, 2016 - science.org
Alzheimer’s disease (AD) is characterized by two molecular pathologies: cerebral β-amyloidosis
in the form of β-amyloid (Aβ) plaques and tauopathy in the form of neurofibrillary tangles…