The metabolism of cancer cells is reprogrammed both by oncogene signaling and by
dysregulation of metabolic enzymes. The resulting altered metabolism supports cellular …

Critical issues in apoptosis include the importance of caspases versus organelle dysfunction,
dominance of anti- versus proapoptotic BCL-2 members, and whether commitment occurs …

… During T cell development in the thymus, each individual T cell precursor generates a
unique T cell antigen receptor by combinatorial rearrangement of T cell antigen receptor gene …

Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event
for mitochondrial dysfunction in vivo has been unclear. tBID, the caspase-activated form of …

… We show that CD8 + T cells deficient in the transcription factors T-… T cells lacking both T-bet
and Eomes differentiate into an interleukin-17–secreting lineage, reminiscent of the helper T …

… lation of mature B and T cells led to massive enlargement deficient mice failed to … had similar
frequencies of CD4 and CD8 T cells (Figure 5A). However, the T cells that accumulate in the …

In animals, cells are dependent on extracellular signals to prevent apoptosis. However, using
growth factor-dependent cells from Bax/Bak-deficient mice, we demonstrate that apoptosis …

… To assess whether BAK was involved in tBID-induced cytochrome c release, we turned to
Bak-deficient mice generated by gene targeting (T. Lindsten and CB Thompson, in prep.). …

The BH3-only proteins Bim and Bad bind to the antiapoptotic Bcl-2 proteins and induce
apoptosis in wild-type cells and cells from eitherbax −/− or bak −/− animals. In contrast, …

… Similarly, overexpression of full-length and truncated caspase 12 (t-caspase 12) induced
cell death in both wild-type and bax − / − bak − / − cells, and t-caspase 12 had a higher killing …