[PDF][PDF] Structure, function, and pharmacology of NMDA receptor channels

V Vyklicky, M Korinek, T Smejkalova, A Balik… - Physiological …, 2014 - researchgate.net
… ANIS N, SHERBY S, GOODNOW R JR, NIWA M, KONNO K, KALLIMOPOULOS T, BUKOWNIK
R, NAKANISHI K, USHERWOOD P, ELDEFRAWI A, ELDEFRAWI M: Structure-activity …

Estradiol acutely potentiates hippocampal excitatory synaptic transmission through a presynaptic mechanism

T Smejkalova, CS Woolley - Journal of Neuroscience, 2010 - Soc Neuroscience
Although recent evidence suggests that the hippocampus is a source of 17β-estradiol (E2),
the physiological role of this neurosteroid E2, as distinct from ovarian E2, is unknown. One …

Cholesterol modulates open probability and desensitization of NMDA receptors

…, J Krusek, A Balik, T Smejkalova… - The Journal of …, 2015 - Wiley Online Library
… Student's t test was used to compare datasets. P < 0.05 was … -801, an NMDAR opens
cumulatively for a mean time of t b … Mean charge transfer conducted by a single NMDAR is: q = t

Multiple ERβ antisera label in ERβ knockout and null mouse tissues

MA Snyder, T Smejkalova, PM Forlano… - Journal of neuroscience …, 2010 - Elsevier
In the process of characterizing a custom-made affinity-purified antiserum for estrogen receptor
beta (ERβ), ck5912, we used a number of common tests for specificity of ck5912 along …

Estrogen mobilizes a subset of estrogen receptor-α-immunoreactive vesicles in inhibitory presynaptic boutons in hippocampal CA1

SA Hart, MA Snyder, T Smejkalova… - Journal of …, 2007 - Soc Neuroscience
Although the classical mechanism of estrogen action involves activation of nuclear transcription
factor receptors, estrogen also has acute effects on neuronal signaling that occur too …

Estradiol facilitates the release of neuropeptide Y to suppress hippocampus-dependent seizures

VA Ledoux, T Smejkalova, RM May… - Journal of …, 2009 - Soc Neuroscience
About one-third of women with epilepsy have a catamenial seizure pattern, in which seizures
fluctuate with the menstrual cycle. Catamenial seizures occur more frequently when the …

[HTML][HTML] Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission

M Korinek, IM Gonzalez-Gonzalez, T Smejkalova… - Scientific Reports, 2020 - nature.com
… To characterize the shortening of NMDAR eEPSCs, we assessed the time of half deactivation
(t 1/2, Fig. 1C,D). Cholesterol depletion reduced t 1/2 from 91 ± 12 ms to 29 ± 7 ms (p = …

[HTML][HTML] Surface expression, function, and pharmacology of disease-associated mutations in the membrane domain of the human GluN2B subunit

…, J Cerny, M Ladislav, T Smejkalova… - Frontiers in molecular …, 2018 - frontiersin.org
N-methyl-D-aspartate receptors (NMDARs), glutamate-gated ion channels, mediate signaling
at the majority of excitatory synapses in the nervous system. Recent sequencing data for …

[HTML][HTML] Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule

…, M Novotny, K Lichnerova, T Smejkalova… - Scientific reports, 2015 - nature.com
N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity and their dysfunction
is implicated in multiple brain disorders. NMDARs can be allosterically modulated by …

Preferential inhibition of tonically over phasically activated NMDA receptors by pregnane derivatives

V Vyklicky, T Smejkalova, B Krausova… - Journal of …, 2016 - Soc Neuroscience
Postsynaptic N-methyl-d-aspartate receptors (NMDARs) phasically activated by presynaptically
released glutamate are critical for synaptic transmission and plasticity. However, under …