Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to escape …

Kir4.1 is an inwardly rectifying K + channel expressed exclusively in glial cells in the central
nervous system. In glia, Kir4.1 is implicated in several functions including extracellular K + …

… Cuddapah VA, Sontheimer H. Molecular interaction and functional regulation of ClC-3 by
Ca2+/calmodulin-dependent protein kinase II (CaMKII) in human malignant glioma. J Biol …

Background Rett syndrome (RTT), a neurodevelopmental disorder that primarily affects girls,
is characterised by a period of apparently normal development until 6–18 months of age …

The blood–brain barrier (BBB) is an evolutionarily conserved, structural, and functional
separation between circulating blood and the central nervous system (CNS). By controlling …

Glioblastoma multiforme is the most common and lethal primary brain cancer in adults. Tumor
cells diffusely infiltrate the brain making focal surgical and radiation treatment challenging. …

Seizures frequently accompany gliomas and often escalate to peritumoral epilepsy.
Previous work revealed the importance of tumor‐derived excitatory glutamate (Glu) release …

Previous reports demonstrate that cell migration in the nervous system is associated with
stereotypic changes in intracellular calcium concentration ([Ca 2+ ] i ), yet the target of these …

Sleep is thought to be restorative to brain energy homeostasis, but it is not clear how this is
achieved. We show here that Drosophila glia exhibit a daily cycle of glial mitochondrial …

Heterozygous pathogenic variants in DNM1 cause developmental and epileptic encephalopathy
(DEE) as a result of a dominant-negative mechanism impeding vesicular fission. Thus …