Under normal physiological conditions, the use of oxygen by cells of aerobic organisms
generates potentially deleterious reactive oxygen metabolites. A chronic state of oxidative stress …

In postindustrial societies, overeating, inactivity, and obesity have emerged as new
challenges in public health. , 2 Considerable effort is now being devoted to determining the …

The main purpose of this article is to provide a critical overview of the currently available
evidence bearing on the validity of the oxidative stress hypothesis of aging, which postulates …

Synchronized oscillations and inhibitory interneurons have important and interconnected
roles within cortical microcircuits. In particular, interneurons defined by the fast-spiking …

Severe behavioural deficits in psychiatric diseases such as autism and schizophrenia have
been hypothesized to arise from elevations in the cellular balance of excitation and inhibition …

Background Fusions involving one of three tropomyosin receptor kinases (TRK) occur in
diverse cancers in children and adults. We evaluated the efficacy and safety of larotrectinib, a …

The hypothesis that oxygen free radicals are causally involved in the aging process was
tested by a study of the effects of simultaneous overexpression of copper-zinc superoxide …

This study was conducted in order to test the concept that oxidative damage is associated
with aging and may be a factor in the modulation of life span in response to variations in …

Attempts to examine the concepts of trust and commitment, on two levels of retail relationships:
the salesperson level as well as the store level, and test their impact on relationship …

This empirical study examines the relationship between total quality management (TQM)
and innovation performance and compares the nature of this relationship against quality …