The locus coeruleus (LC), a small brainstem nucleus, is the primary source of the neuromodulator
norepinephrine (NE) in the brain. The LC receives input from widespread brain regions…

Olfactory bulb (OB) interneurons are continuously renewed throughout an animal's lifespan.
Despite extensive investigation of this phenomenon, little is known about bulbar circuitry …

Arousal responses linked to locus coeruleus noradrenergic (LC-NA) activity affect cognition.
However, the mechanisms that control modes of LC-NA activity remain unknown. Here, we …

The generation of new cells in the adult brain reveals a new form of plasticity in the neuronal
network. New cells are constantly migrating to and integrating into the pre-existing neuronal …

Noradrenaline released from the locus coeruleus (LC) is a ubiquitous neuromodulator 1 , 2 ,
3 – 4 that has been linked to multiple functions including arousal 5 , 6 , 7 – 8 , action and …

Biological neural networks adapt and learn in diverse behavioral contexts. Artificial neural
networks (ANNs) have exploited biological properties to solve complex problems. However, …

Rett syndrome (RTT) arises from loss-of-function mutations in methyl-CpG binding protein 2
gene (Mecp2), but fundamental aspects of its physiological mechanisms are unresolved. …

Plasticity of cortical responses in vivo involves activity-dependent changes at synapses, but
the manner in which different forms of synaptic plasticity act together to create functional …

Calcium ions are ubiquitous signalling molecules in all multicellular organisms, where they
mediate diverse aspects of intracellular and extracellular communication over widely varying …

Sensorimotor behaviors require processing of behaviorally relevant sensory cues and the
ability to select appropriate responses from a vast behavioral repertoire. Modulation by the …