DNAJC6 Mutations Associated With Early‐Onset Parkinson's Disease
…, AJA Kievit, LB Jardim, W Mandemakers… - Annals of …, 2016 - Wiley Online Library
Objective DNAJC6 mutations were recently described in two families with autosomal
recessive juvenile parkinsonism (onset age < 11), prominent atypical signs, poor or absent …
recessive juvenile parkinsonism (onset age < 11), prominent atypical signs, poor or absent …
MicroRNAs in Alzheimer's disease
C Delay, W Mandemakers, SS Hébert - Neurobiology of disease, 2012 - Elsevier
Alzheimer's disease (AD) is a complex neurodegenerative disorder and is the most common
form of dementia in the elderly. Accumulating evidence in AD research suggests that …
form of dementia in the elderly. Accumulating evidence in AD research suggests that …
A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases
W Mandemakers, VA Morais… - Journal of cell …, 2007 - journals.biologists.com
… Wim Mandemakers … Wim Mandemakers … Wim Mandemakers is a visiting
postdoctoral researcher of the FWO. VM is a Marie Curie Fellow of the EU. …
postdoctoral researcher of the FWO. VM is a Marie Curie Fellow of the EU. …
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression
…, AS Papadopoulou, W Mandemakers… - Proceedings of the …, 2008 - National Acad Sciences
Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well
established, fairly little is known about the molecular mechanisms affecting Aβ generation in …
established, fairly little is known about the molecular mechanisms affecting Aβ generation in …
Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function
…, D Haddad, C Frezza, W Mandemakers… - EMBO molecular …, 2009 - embopress.org
… (top panel) in control (w pink1 REV ) and pink1 mutant (w pink1 B9 ). Drosophila third instar
… bar graphs (eight synapses from w pink1 REV and 10 synapses from w pink1 B9 ) and error …
… bar graphs (eight synapses from w pink1 REV and 10 synapses from w pink1 B9 ) and error …
[PDF][PDF] LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis
…, R da Cunha, G van den Bogaart, W Mandemakers… - Neuron, 2012 - cell.com
LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic
function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using …
function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using …
The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy
…, C Van Humbeeck, W Mandemakers… - Human molecular …, 2014 - academic.oup.com
Loss-of-function mutations in PARK2, the gene encoding the E3 ubiquitin ligase Parkin, are
the most frequent cause of recessive Parkinson's disease (PD). Parkin translocates from the …
the most frequent cause of recessive Parkinson's disease (PD). Parkin translocates from the …
Parkin interacts with Ambra1 to induce mitophagy
…, H Hofkens, W Mandemakers… - Journal of …, 2011 - Soc Neuroscience
Mutations in the gene encoding Parkin are a major cause of recessive Parkinson's disease.
Recent work has shown that Parkin translocates from the cytosol to depolarized …
Recent work has shown that Parkin translocates from the cytosol to depolarized …
The POU proteins Brn-2 and Oct-6 share important functions in Schwann cell development
M Jaegle, M Ghazvini, W Mandemakers… - Genes & …, 2003 - genesdev.cshlp.org
The genetic hierarchy that controls myelination of peripheral nerves by Schwann cells includes
the POU domain Oct-6/Scip/Tst-1and the zinc-finger Krox-20/Egr2 transcription factors. …
the POU domain Oct-6/Scip/Tst-1and the zinc-finger Krox-20/Egr2 transcription factors. …
The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination
T Karnezis, W Mandemakers, JL McQualter… - Nature …, 2004 - nature.com
Inhibitors associated with CNS myelin are thought to be important in the failure of axons to
regenerate after spinal cord injury and in other neurodegenerative disorders. Here we show …
regenerate after spinal cord injury and in other neurodegenerative disorders. Here we show …