Coagulation factor II, or prothrombin, is a multi-domain glycoprotein that is essential for life
and a key target of anticoagulant therapy. In plasma, prothrombin circulates in two forms at …

Optogenetics is now a widely accepted tool for spatiotemporal manipulation of neuronal activity.
However, a majority of optogenetic approaches use binary on/off control schemes. Here, …

… All data are expressed as mean±sem All light pulses are 473 nm, 1 W cm −2 unless … All
data are expressed as mean±sem All light pulses are 473 nm, 1 W cm −2 unless otherwise noted…

Ret signaling is critical for formation of the enteric nervous system (ENS) because Ret
activation promotes ENS precursor survival, proliferation, and migration and provides trophic …

Anti-phosphatidylserine/prothrombin (aPS/PT) antibodies are often detected in patients with
antiphospholipid syndrome (APS), but how aPS/PT engage prothrombin at the molecular …

β 2 -Glycoprotein I (β 2 GPI) is an abundant plasma protein displaying phospholipid-binding
properties. Because it binds phospholipids, it is a target of antiphospholipid antibodies (aPLs…

We determined the role of carboxyl-terminal regulation of NOPR (nociceptin, orphanin FQ
receptor) signaling and function. We mutated C-terminal serine and threonine residues and …

β 2 -glycoprotein I (β 2 GPI) is an abundant multidomain plasma protein that plays various
roles in the clotting and complement cascades. It is also the main target of antiphospholipid …

The endogenous neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP)
is secreted by both neuronal and non-neuronal cells in the brain and spinal cord, in …

Hirschsprung disease (distal intestinal aganglionosis, HSCR) is a multigenic disorder with
incomplete penetrance, variable expressivity, and a strong male gender bias. Recent studies …