Structure and function of cyclic nucleotide-gated channels

WN Zagotta, SA Siegelbaum - Annual review of neuroscience, 1996 - annualreviews.org
… induced by cyclic nucleotide binding (Gordon & Zagotta 1995a). In the olfactory CNG … &
Zagotta 1995b). Using chimeras between the rod and olfactory channels, Gordon & Zagotta (…

CNG and HCN channels: two peas, one pod

KB Craven, WN Zagotta - Annu. Rev. Physiol., 2006 - annualreviews.org
▪ Abstract Cyclic nucleotide–activated ion channels play a fundamental role in a variety of
physiological processes. By opening in response to intracellular cyclic nucleotides, they …

Cyclic nucleotide-gated ion channels

K Matulef, WN Zagotta - Annual review of cell and …, 2003 - annualreviews.org
▪ Abstract Cyclic nucleotide-gated (CNG) ion channels were first discovered in rod photoreceptors,
where they are responsible for the primary electrical signal of the photoreceptor in …

Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation

T Hoshi, WN Zagotta, RW Aldrich - Science, 1990 - science.org
The potassium channels encoded by the Drosophila Shaker gene activate and inactivate
rapidly when the membrane potential becomes more positive. Site-directed mutagenesis and …

Restoration of Inactivation in Mutants of Shaker Potassium Channels by a Peptide Derived from ShB

WN Zagotta, T Hoshi, RW Aldrich - Science, 1990 - science.org
Site-directed mutagenesis experiments have suggested a model for the inactivation mechanism
of Shaker potassium channels from Drosophila melanogaster. In this model, the first 20 …

Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region

T Hoshi, WN Zagotta, RW Aldrich - Neuron, 1991 - cell.com
Shaker potassium channels inactivate and recover from inactivation with multiple exponential
components, suggesting the presence of multiple inactivation processes. We describe two …

Shaker potassium channel gating. III: Evaluation of kinetic models for activation.

WN Zagotta, T Hoshi, RW Aldrich - The Journal of general physiology, 1994 - rupress.org
Predictions of different classes of gating models involving identical conformational changes
in each of four subunits were compared to the gating behavior of Shaker potassium …

Structural basis for modulation and agonist specificity of HCN pacemaker channels

WN Zagotta, NB Olivier, KD Black, EC Young, R Olson… - Nature, 2003 - nature.com
The family of hyperpolarization-activated, cyclic nucleotide-modulated (HCN) channels are
crucial for a range of electrical signalling, including cardiac and neuronal pacemaker activity, …

Shaker potassium channel gating. II: Transitions in the activation pathway.

WN Zagotta, T Hoshi, J Dittman… - The Journal of general …, 1994 - rupress.org
Voltage-dependent gating behavior of Shaker potassium channels without N-type inactivation
(ShB delta 6-46) expressed in Xenopus oocytes was studied. The voltage dependence of …

Crystal structure of the plant dual-affinity nitrate transporter NRT1. 1

…, JR Bankston, J Payandeh, TR Hinds, WN Zagotta… - Nature, 2014 - nature.com
… We also thank members of the Zheng laboratory, Zagotta laboratory, Xu laboratory and H.
Zheng for discussion and help. This work is supported by the Howard Hughes Medical Institute …