Structural changes of neurons in the brain during aging are complex and not well understood.
Neurons have significant homeostatic control of essential brain functions, including …

… Vasoactive effects of Ab in isolated human cerebrovessels and in a transgenic mouse
model of Alzheimer’s disease: Role of inflammation. Neurol Res 2003; 25: 642–651 …

Stressful life events have been implicated clinically in the pathogenesis of mental illness,
but the neural substrates that may account for this observation remain poorly understood. …

In neurodegenerative disorders, such as Alzheimer’s disease, neuronal dendrites and
dendritic spines undergo significant pathological changes. Because of the determinant role of …

Both the hippocampus and the medial prefrontal cortex (mPFC) play an important role in the
negative feedback regulation of hypothalamic–pituitary–adrenal (HPA) activity during …

The prefrontal cortex (PFC) plays an important role in higher cognitive processes, and in the
regulation of stress-induced hypothalamic–pituitary–adrenal (HPA) activity. Here we …

Anatomical alterations in the medial prefrontal cortex (mPFC) are associated with
hypothalamopituitary adrenal (HPA) axis dysregulation, altered stress hormone levels, and …

Cognitive impairment in normal aging and neurodegenerative diseases is accompanied by
altered morphologies on multiple scales. Understanding of the role of these structural …

Alterations in neuronal morphology occur in primate cerebral cortex during normal aging,
vary depending on the neuronal type, region and cortical layer, and have been related to …

This study was designed to explore the possibility that caloric restriction (CR) may benefit
Alzheimer's disease (AD) by preventing β‐amyloid (Aβ) neuropathology pivotal to the initiation …