Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the mammalian
central nervous system, are mediated via signaling by ionotropic glutamate receptors (…

Ionotropic glutamate receptors are ligand-gated ion channels that mediate rapid information
transfer at most excitatory synapses in the brain. Crystal structures are now available for the …

Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central
nervous system and function by opening a transmembrane ion channel upon binding of …

Ionotropic glutamate receptors (iGluRs) are ligand‐gated ion channels that open their ion‐conducting
pores in response to the binding of agonist glutamate. In recent years, significant …

Versatile superresolution imaging methods, able to give dynamic information of endogenous
molecules at high density, are still lacking in biological science. Here, superresolved …

Precise regulation of calcium homeostasis is essential for many physiological functions. The
Ca 2+ -selective transient receptor potential (TRP) channels TRPV5 and TRPV6 play vital …

Pain therapy has remained conceptually stagnant since the opioid crisis, which highlighted
the dangers of treating pain with opioids. An alternative addiction-free strategy to …

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-subtype ionotropic glutamate
receptors mediate fast excitatory neurotransmission throughout the central nervous system…

The transient receptor potential channel TRPM7 is a master regulator of the organismal
balance of divalent cations that plays an essential role in embryonic development, immune …

Calcium-selective transient receptor potential vanilloid subfamily member 6 (TRPV6)
channels play a critical role in calcium uptake in epithelial tissues 1 , 2 , 3 , 4 . Altered TRPV6 …