User profiles for A. M. Brennan
Andrea BrennanQueen's University Verified email at queensu.ca Cited by 301 |
Drug Insight: the role of leptin in human physiology and pathophysiology—emerging clinical applications
AM Brennan, CS Mantzoros - Nature clinical practice Endocrinology & …, 2006 - nature.com
Leptin is an adipocyte-secreted hormone with a key role in energy homeostasis. Studies in
animal models, in humans with congenital complete leptin deficiency, and observational and …
animal models, in humans with congenital complete leptin deficiency, and observational and …
Intermuscular adipose tissue in metabolic disease
Intermuscular adipose tissue (IMAT) is a distinct adipose depot described in early reports as
a ‘fatty replacement’ or ‘muscle fat infiltration’ that was linked to ageing and neuromuscular …
a ‘fatty replacement’ or ‘muscle fat infiltration’ that was linked to ageing and neuromuscular …
Hajdu‐Cheney syndrome: evolution of phenotype and clinical problems
AM Brennan, RM Pauli - American journal of medical genetics, 2001 - Wiley Online Library
Hajdu‐Cheney syndrome is a rare, autosomal dominant disorder comprising acroosteolysis
of the distal phalanges with associated digital abnormalities, distinctive craniofacial and …
of the distal phalanges with associated digital abnormalities, distinctive craniofacial and …
NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation
AM Brennan, S Won Suh, S Joon Won… - Nature …, 2009 - nature.com
… Neurons were loaded for 30 min with 4 nM Fura-2 am (Molecular Probes) and washed once
with BSS before imaging. Images were acquired at 1-min intervals with 30-ms exposures, …
with BSS before imaging. Images were acquired at 1-min intervals with 30-ms exposures, …
Glucose and NADPH oxidase drive neuronal superoxide formation in stroke
…, H Ma, M Van Hoecke, AM Brennan… - Annals of Neurology …, 2008 - Wiley Online Library
Objective Hyperglycemia has been recognized for decades to be an exacerbating factor in
ischemic stroke, but the mechanism of this effect remains unresolved. Here, we evaluated …
ischemic stroke, but the mechanism of this effect remains unresolved. Here, we evaluated …
Children of Katrina: Lessons learned about postdisaster symptoms and recovery patterns
ME Kronenberg, TC Hansel, AM Brennan… - Child …, 2010 - Wiley Online Library
… Brennan… Brennan … I don’t know what the future holds, but after surviving Katrina, I am
sure I can handle it. (14-year-old high-school student 1 year after Hurricane Katrina) …
sure I can handle it. (14-year-old high-school student 1 year after Hurricane Katrina) …
An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans
…, KA West, AJ Degar, AM Brennan… - Science translational …, 2019 - science.org
… Miller, AM Brennan, Translational development of microbiome-based therapeutics:
Kinetics of E. coli Nissle and engineered strains in humans and nonhuman primates. Clin. …
Kinetics of E. coli Nissle and engineered strains in humans and nonhuman primates. Clin. …
[HTML][HTML] Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial
Background Coffee consumption has been associated with a lower risk of type 2 diabetes in
prospective cohort studies, but the underlying mechanisms remain unclear. The aim of this …
prospective cohort studies, but the underlying mechanisms remain unclear. The aim of this …
Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study
…, VV Sethuraman, RJ Riese, CB Kurtz, AM Brennan - Nature …, 2021 - nature.com
Phenylketonuria (PKU) is a rare disease caused by biallelic mutations in the PAH gene that
result in an inability to convert phenylalanine (Phe) to tyrosine, elevated blood Phe levels …
result in an inability to convert phenylalanine (Phe) to tyrosine, elevated blood Phe levels …
Efficacy of metreleptin in obese patients with type 2 diabetes: cellular and molecular pathways underlying leptin tolerance
HS Moon, G Matarese, AM Brennan… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Metreleptin has been efficacious in improving metabolic control in patients with
lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. …
lipodystrophy, but its efficacy has not been tested in obese patients with type 2 diabetes. …