Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance
The nonopioid actions of spinal dynorphin may promote aspects of abnormal pain after
nerve injury. Mechanistic similarities have been suggested between opioid tolerance and …
nerve injury. Mechanistic similarities have been suggested between opioid tolerance and …
Reversal of experimental neuropathic pain by T-type calcium channel blockers
A Dogrul, LR Gardell, MH Ossipov, FC Tulunay, J Lai… - Pain, 2003 - Elsevier
Experimental nerve injury results in exaggerated responses to tactile and thermal stimuli
that resemble some aspects of human neuropathic pain. Neuronal hyperexcitability and …
that resemble some aspects of human neuropathic pain. Neuronal hyperexcitability and …
Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors
The rostroventromedial medulla (RVM) is an important source of descending modulatory
systems that both inhibit and facilitate pain at the level of the spinal cord. Noxious stimuli can …
systems that both inhibit and facilitate pain at the level of the spinal cord. Noxious stimuli can …
Involvement of descending serotonergic and noradrenergic pathways in CB1 receptor-mediated antinociception
Cannabinoids produce antinociceptive and antihyperalgesic effects mainly through activation
of the inhibitory CB1 receptors. The demonstration that antinociceptive effects of systemic …
of the inhibitory CB1 receptors. The demonstration that antinociceptive effects of systemic …
Investigation of self-propulsion of DARPA Suboff by RANS method
In this study, the resistance and self-propulsion analyses of the benchmark DARPA Suboff
with E1619 propeller have been done using Computational Fluid Dynamics (CFD) method. …
with E1619 propeller have been done using Computational Fluid Dynamics (CFD) method. …
Peripheral and spinal antihyperalgesic activity of SIB-1757, a metabotropic glutamate receptor (mGLUR5) antagonist, in experimental neuropathic pain in rats
Recent studies suggest a role of Group 1 metabotropic glutamate receptors in mediating the
development of spinal hypersensitivity in some pain states. Here, the possible role of mGluR …
development of spinal hypersensitivity in some pain states. Here, the possible role of mGluR …
Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via …
O Yanarates, A Dogrul, V Yildirim, A Sahin… - The Journal of the …, 2010 - pubs.asahq.org
Background Tramadol is an analgesic drug, and its mechanism of action is believed to be
mediated by the mu-opioid receptor. A further action of tramadol has been identified as …
mediated by the mu-opioid receptor. A further action of tramadol has been identified as …
Systemic morphine produce antinociception mediated by spinal 5‐HT7, but not 5‐HT1A and 5‐HT2 receptors in the spinal cord
Background and purpose: The serotonergic system within the spinal cord have been proposed
to play an important role in the analgesic effects of systemic morphine. Currently, seven …
to play an important role in the analgesic effects of systemic morphine. Currently, seven …
Scale effect on ship resistance components and form factor
To design eco-friendly ships, the hydrodynamic behaviour of the hull has to be estimated
precisely. The first and foremost one is the ship resistance, which is closely related to the …
precisely. The first and foremost one is the ship resistance, which is closely related to the …
Systemic paracetamol-induced analgesic and antihyperalgesic effects through activation of descending serotonergic pathways involving spinal 5-HT7 receptors
Although some studies have shown the essential role of descending serotonergic pathways
and spinal 5-HT 1A , 5-HT 2A , or 5-HT 3 receptors in the antinociceptive effects of …
and spinal 5-HT 1A , 5-HT 2A , or 5-HT 3 receptors in the antinociceptive effects of …