User profiles for A. Kuhara

Atsushi Kuhara

Institute for integrative neurobiology, Konan University
Verified email at center.konan-u.ac.jp
Cited by 2066

The involvement of IL-23 and the Th17 pathway in periodontitis

H Ohyama, N Kato-Kogoe, A Kuhara… - Journal of dental …, 2009 - journals.sagepub.com
Interleukin (IL)-23 is an essential cytokine involved in expansion of the Th17 lineage, which
is associated with many immune-related destructive tissue diseases. We hypothesized that …

[PDF][PDF] Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of otd/Otx

JS Satterlee, H Sasakura, A Kuhara, M Berkeley, I Mori… - Neuron, 2001 - cell.com
Temperature is a critical modulator of animal metabolism and behavior, yet the mechanisms
underlying the development and function of thermosensory neurons are poorly understood. …

[PDF][PDF] Ca2+ signaling via the neuronal calcium sensor-1 regulates associative learning and memory in C. elegans

…, E De Castro, E Guarin, H Sasakura, A Kuhara… - Neuron, 2001 - cell.com
On a radial temperature gradient, C. elegans worms migrate, after conditioning with food,
toward their cultivation temperature and move along this isotherm. This experience-dependent …

Insulin-like signaling and the neural circuit for integrative behavior in C. elegans

E Kodama, A Kuhara, A Mohri-Shiomi… - Genes & …, 2006 - genesdev.cshlp.org
Caenorhabditis elegans exhibits a food-associated behavior that is modulated by the past
cultivation temperature. Mutations in INS-1, the homolog of human insulin, caused the defect …

[PDF][PDF] Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6

A Kuhara, H Inada, I Katsura, I Mori - Neuron, 2002 - cell.com
Animals sense and adapt to variable environments by regulating appropriate sensory signal
transduction pathways. Here, we show that calcineurin plays a key role in regulating the …

Temperature signaling underlying thermotaxis and cold tolerance in Caenorhabditis elegans

A Takeishi, N Takagaki, A Kuhara - Nature's Gift to Neuroscience, 2022 - taylorfrancis.com
Caenorhabditis elegans has a simple nervous system of 302 neurons. It however senses
environmental cues incredibly precisely and produces various behaviors by processing …

[HTML][HTML] Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans

A Ohta, T Ujisawa, S Sonoda, A Kuhara - Nature communications, 2014 - nature.com
Temperature is a critical environmental stimulus that has a strong impact on an organism’s
biochemistry. Animals can respond to changes in ambient temperature through behaviour or …

Temperature Sensing by an Olfactory Neuron in a Circuit Controlling Behavior of C. elegans

A Kuhara, M Okumura, T Kimata, Y Tanizawa… - Science, 2008 - science.org
Temperature is an unavoidable environmental cue that affects the metabolism and behavior
of any creature on Earth, yet how animals perceive temperature is poorly understood. The …

Worm thermotaxis: a model system for analyzing thermosensation and neural plasticity

I Mori, H Sasakura, A Kuhara - Current opinion in neurobiology, 2007 - Elsevier
Elucidation of the principal mechanism for sensory transduction, learning and memory is a
fundamental question in neurobiology. The simple nervous system composed of only 302 …

Bidirectional regulation of thermotaxis by glutamate transmissions in Caenorhabditis elegans

N Ohnishi, A Kuhara, F Nakamura, Y Okochi… - The EMBO journal, 2011 - embopress.org
In complex neural circuits of the brain, massive information is processed with neuronal
communication through synaptic transmissions. It is thus fundamental to delineate information …