Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

T Yamauchi, J Kamon, Y Ito, A Tsuchida, T Yokomizo… - Nature, 2003 - nature.com
Corrigendum (2004) Adiponectin (also known as 30-kDa adipocyte complement-related
protein; Acrp30) 1 , 2 , 3 , 4 is a hormone secreted by adipocytes that acts as an antidiabetic 5 , …

Expert Consensus Guidelines: How to safely perform minimally invasive anatomic liver resection

…, M Nakamura, M Yamamoto, A Tsuchida… - Journal of Hepato …, 2022 - Wiley Online Library
Background The concept of minimally invasive anatomic liver resection (MIALR) is gaining
popularity. However, specific technical skills need to be acquired to safely perform MIALR. …

Brain‐derived neurotrophic factor ameliorates lipid metabolism in diabetic mice

A Tsuchida, T Nonomura, T Nakagawa… - Diabetes, obesity …, 2002 - Wiley Online Library
Aim: It has been reported previously that brain‐derived neurotrophic factor (BDNF) regulates
blood glucose metabolism in rodent obese diabetic models such as C57BL/KsJ‐lepr db /…

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions

…, N Kubota, T Kubota, Y Ito, J Kamon, A Tsuchida… - Nature medicine, 2007 - nature.com
Adiponectin plays a central role as an antidiabetic and antiatherogenic adipokine. AdipoR1
and AdipoR2 serve as receptors for adiponectin in vitro, and their reduction in obesity seems …

[PDF][PDF] Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake

…, S Okamoto, T Shiuchi, R Suzuki, H Satoh, A Tsuchida… - Cell metabolism, 2007 - cell.com
Adiponectin has been shown to stimulate fatty acid oxidation and enhance insulin sensitivity
through the activation of AMP-activated protein kinase (AMPK) in the peripheral tissues. The …

[HTML][HTML] Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity

A Tsuchida, T Yamauchi, Y Ito, Y Hada, T Maki… - Journal of Biological …, 2004 - ASBMB
Adiponectin/Acrp30 is a hormone secreted by adipocytes, which acts as an antidiabetic and
antiatherogenic adipokine. We reported previously that AdipoR1 and -R2 serve as receptors …

[HTML][HTML] The mechanisms by which both heterozygous peroxisome proliferator-activated receptor γ (PPARγ) deficiency and PPARγ agonist improve insulin resistance

…, Y Terauchi, K Tobe, H Miki, A Tsuchida… - Journal of Biological …, 2001 - ASBMB
Peroxisome proliferator-activated receptor (PPAR) γ is a ligand-activated transcription factor
and a member of the nuclear hormone receptor superfamily that is thought to be the master …

Photoinduced DNA cleavage via electron transfer: demonstration that guanine residues located 5'to guanine are the most electron-donating sites

…, H Sugiyama, K Nakatani, A Tsuchida… - Journal of the …, 1995 - ACS Publications
There has long been great interest in the one-electron oxidations occurring in DNA in connection
with DNA damage caused by ionizing radiation, oxidizing agents, and photoirradiation …

[HTML][HTML] Inhibition of RXR and PPARγ ameliorates diet-induced obesity and type 2 diabetes

…, N Kubota, Y Terauchi, A Tsuchida… - The Journal of …, 2001 - Am Soc Clin Investig
PPARγ is a ligand-activated transcription factor and functions as a heterodimer with a
retinoid X receptor (RXR). Supraphysiological activation of PPARγ by thiazolidinediones can …

Peroxisome proliferator–activated receptor (PPAR) α activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue …

A Tsuchida, T Yamauchi, S Takekawa, Y Hada, Y Ito… - Diabetes, 2005 - Am Diabetes Assoc
We examined the effects of activation of peroxisome proliferator–activated receptor (PPAR)α,
PPARγ, and both of them in combination in obese diabetic KKAy mice and investigated the …