Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene
mutations that perturb lysosomal homeostasis. LSDs mainly stem from deficiencies in …

… First, blood–brain barrier (BBB)-localized receptors and transporters, including P glycoprotein
1 transporter (also known as ATP-binding cassette subfamily B member 1, ABCB1) and …

Background Although the insulin-producing pancreatic β-cells are quite capable of adapting
to both acute and chronic changes in metabolic demand, persistently high demand for …

… cell bodies (B, arrows) and neurites (B, inset). Most AVs at 6 h after vinblastine were decorated
by silver-enhanced immunogold-conjugated cathepsin D antibodies. Scale bars, 500 nm. …

Background Upadacitinib, an oral selective Janus kinase (JAK) inhibitor, is under
investigation for the treatment of Crohn’s disease. Methods In two phase 3 induction trials (U-EXCEL …

Inflammation promotes regeneration of injured tissues through poorly understood mechanisms,
some of which involve interleukin (IL)-6 family members, the expression of which is …

… b Patients for whom a single location was not assigned. c Includes NHSN-defined "other"
(OTH) procedures. d White blood cell count <4,000 cells/mm3 or >12,000 cells/mm3 (>15,000 …

… To ensure that the moving citations variable is not just a proxy for these other factors, we
inserted in equation l(b) a regional dummy variable. This regional control variable is not …

Protein aggregation can lead to major disturbances of cellular processes and is associated
with several diseases. We report kinetic and equilibrium data by ThT fluorescence and …

… b, Mean percentage and total number of unique spectra in each organ sampled from the
two mouse groups. c, Relative abundance (normalized to total ion current (TIC)) of the 30 most …