The move from reading to writing the human genome offers new opportunities to improve
human health. The United States National Institutes of Health (NIH) Somatic Cell Genome …

… The closest proximal marker to tg, D8Mit78, was defined in the intercross, where it was
predicted to lie 0.04 ± 0.05 cM proximal to tgla (Figure 1). Only the Lyl1 locus remained …

Expansions of a hexanucleotide repeat (GGGGCC) in the noncoding region of the C9orf72
gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and …

… strength meter was positioned vertically, with the triangular metal transducer situated 40
cm … individually into the center of the arena and infrared beams record distance traveled (cm), …

… A one cM resolution map was then constructed (Figure 3A), allowing the exclusion of several
candidate genes, including those encoding two serotonin receptors and neural syndecan-3…

… The total time upright, numbers of 5.5 × 5.5 cm grid squares crossed, and number of … SMN
expression and marked amelioration of the SMA phenotype (Lutz et al., 2011). After crossing …

… to histotomography for centimeter-size samples at submicron voxel resolutions (Yakovlev
et al., 2021) will be particularly useful for studying samples of millimeter to centimeter scale. …

The challenge of precision medicine is to model complex interactions among DNA variants,
phenotypes, development, environments, and treatments. We address this challenge by …

… This study was supported by SMA Foundation grants to CM Lutz, L. Pellizzoni, CE Henderson,
UR Monani, and Regeneron Pharmaceuticals. Additionally, UR Monani was supported by …

Gene replacement and pre-mRNA splicing modifier therapies represent breakthrough gene
targeting treatments for the neuromuscular disease spinal muscular atrophy (SMA), but …