Short-term fasting induces profound neuronal autophagy
M Alirezaei, CC Kemball, CT Flynn, MR Wood… - Autophagy, 2010 - Taylor & Francis
Disruption of autophagy—a key homeostatic process in which cytosolic components are
degraded and recycled through lysosomes—can cause neurodegeneration in tissue culture …
degraded and recycled through lysosomes—can cause neurodegeneration in tissue culture …
Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis
… Quantification of gene expression was made relative to endogenous reference genes by
calculating the differences in Ct (∆Ct) and relative values determined by 2(-∆∆Ct). Western blot …
calculating the differences in Ct (∆Ct) and relative values determined by 2(-∆∆Ct). Western blot …
Coxsackievirus Infection Induces Autophagy-Like Vesicles and Megaphagosomes in Pancreatic Acinar Cells In Vivo
CC Kemball, M Alirezaei, CT Flynn, MR Wood… - Journal of …, 2010 - Am Soc Microbiol
Autophagy can play an important part in protecting host cells during virus infection, and
several viruses have developed strategies by which to evade or even exploit this homeostatic …
several viruses have developed strategies by which to evade or even exploit this homeostatic …
[HTML][HTML] Disruption of neuronal autophagy by infected microglia results in neurodegeneration
There is compelling evidence to support the idea that autophagy has a protective function in
neurons and its disruption results in neurodegenerative disorders. Neuronal damage is well-…
neurons and its disruption results in neurodegenerative disorders. Neuronal damage is well-…
[PDF][PDF] Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo
M Alirezaei, CT Flynn, MR Wood, JL Whitton - Cell host & microbe, 2012 - cell.com
Autophagy protects against many infections by inducing the lysosomal-mediated degradation
of invading pathogens. However, previous in vitro studies suggest that some enteroviruses …
of invading pathogens. However, previous in vitro studies suggest that some enteroviruses …
Coxsackievirus can exploit LC3 in both autophagy-dependent and-independent manners in vivo
M Alirezaei, CT Flynn, MR Wood, S Harkins… - Autophagy, 2015 - Taylor & Francis
… (A) A schematic summary of proLC3 processing into LC3-I and LC3-II is shown, and includes
the relevant amino acid residue at the Ct of the protein (see text). The Ct residues of the …
the relevant amino acid residue at the Ct of the protein (see text). The Ct residues of the …
[HTML][HTML] Coxsackievirus B3 Inhibits Antigen Presentation In Vivo, Exerting a Profound and Selective Effect on the MHC Class I Pathway
CC Kemball, S Harkins, JK Whitmire, CT Flynn… - PLoS …, 2009 - journals.plos.org
Many viruses encode proteins whose major function is to evade or disable the host T cell
response. Nevertheless, most viruses are readily detected by host T cells, and induce relatively …
response. Nevertheless, most viruses are readily detected by host T cells, and induce relatively …
Antigen-specific naive CD8+ T cells produce a single pulse of IFN-γ in vivo within hours of infection, but without antiviral effect
MP Hosking, CT Flynn, JL Whitton - The Journal of Immunology, 2014 - journals.aai.org
In vitro studies have shown that naive CD8+ T cells are unable to express most of their
effector proteins until after at least one round of cell division has taken place. We have …
effector proteins until after at least one round of cell division has taken place. We have …
In Vivo Ablation of Type I Interferon Receptor from Cardiomyocytes Delays Coxsackieviral Clearance and Accelerates Myocardial Disease
N Althof, S Harkins, CC Kemball, CT Flynn… - Journal of …, 2014 - Am Soc Microbiol
Acute coxsackievirus B3 (CVB3) infection is one of the most prevalent causes of acute
myocarditis, a disease that frequently is identified only after the sudden death of apparently …
myocarditis, a disease that frequently is identified only after the sudden death of apparently …
Effects of simian immunodeficiency virus on the circadian rhythms of body temperature and gross locomotor activity
…, MCG Marcondes, CT Flynn… - Proceedings of the …, 2007 - National Acad Sciences
In monkeys infected with simian immunodeficiency virus (SIV), changes in body temperature
and locomotor activity occur after the acute retroviral syndrome stage of the disease. …
and locomotor activity occur after the acute retroviral syndrome stage of the disease. …