[HTML][HTML] Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke
…, M Gelderblom, P Chunduri, C Bernreuther… - Cell death & …, 2013 - nature.com
Multi-protein complexes called inflammasomes have recently been identified and shown to
contribute to cell death in tissue injury. Intravenous immunoglobulin (IVIg) is an FDA-…
contribute to cell death in tissue injury. Intravenous immunoglobulin (IVIg) is an FDA-…
Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke
…, A Weymar, C Bernreuther… - Blood, The Journal …, 2012 - ashpublications.org
The devastating effect of ischemic stroke is attenuated in mice lacking conventional and
unconventional T cells, suggesting that inflammation enhances tissue damage in cerebral …
unconventional T cells, suggesting that inflammation enhances tissue damage in cerebral …
Deposition of hyperphosphorylated tau in cerebellum of PS1 E280A Alzheimer's disease
…, J Matschke, C Bernreuther, C Hagel… - Brain …, 2011 - Wiley Online Library
Early‐onset familial Alzheimer's disease (AD) caused by presenilin‐1 mutation E280A (PS1‐E280A)
presents wide clinical and neuropathological variabilities. We characterized …
presents wide clinical and neuropathological variabilities. We characterized …
The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex
E Jorissen, J Prox, C Bernreuther, S Weber… - Journal of …, 2010 - Soc Neuroscience
… , and incubated in 2N HCl for 20 min at 37C, neutralized in 0.1 m borate buffer, pH 8.5, for …
goat serum (DAKO) and incubated ON at 4C with 0.1 mg/ml unconjugated fab fragment goat-…
goat serum (DAKO) and incubated ON at 4C with 0.1 mg/ml unconjugated fab fragment goat-…
Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats
C Bühnemann, A Scholz, C Bernreuther, CY Malik… - Brain, 2006 - academic.oup.com
… After post-fixation overnight, brains were cryoprotected and frozen in methylbutane at −80C.
Coronal … Primary antibodies, applied at 4C overnight, were monoclonal mouse antibodies to …
Coronal … Primary antibodies, applied at 4C overnight, were monoclonal mouse antibodies to …
CLP1 links tRNA metabolism to progressive motor-neuron loss
T Hanada, S Weitzer, B Mair, C Bernreuther… - Nature, 2013 - nature.com
CLP1 was the first mammalian RNA kinase to be identified. However, determining its in vivo
function has been elusive. Here we generated kinase-dead Clp1 (Clp1 K/K ) mice that show …
function has been elusive. Here we generated kinase-dead Clp1 (Clp1 K/K ) mice that show …
[HTML][HTML] Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function
CLP1 is a RNA kinase involved in tRNA splicing. Recently, CLP1 kinase-dead mice were
shown to display a neuromuscular disorder with loss of motor neurons and muscle paralysis. …
shown to display a neuromuscular disorder with loss of motor neurons and muscle paralysis. …
[HTML][HTML] Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers
…, S Gelperina, O Maksimenko, C Bernreuther… - PloS one, 2011 - journals.plos.org
… Switzerland) at a heating rate of 20C/min under argon. The samples were measured in
aluminium pans. The temperature range was −50C to 200C. A blank aluminium pan was used as …
aluminium pans. The temperature range was −50C to 200C. A blank aluminium pan was used as …
[HTML][HTML] Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever
…, T Rieger, M Neumann, C Bernreuther… - PLoS neglected …, 2014 - journals.plos.org
… (c x ,c y ) was calculated for each drug combination (c x ,c y ). A ratio >1 indicates synergy (ie
for (c x ,c … a ratio <1 indicates antagonism (ie for (c x ,c y ) the virus titer for predicted additive …
for (c x ,c … a ratio <1 indicates antagonism (ie for (c x ,c y ) the virus titer for predicted additive …
[HTML][HTML] Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo
…, J Prox, B Puig, MA Kluth, C Bernreuther… - Molecular …, 2011 - Springer
… C and proves a role of ADAM10 in shedding of PrP C in vivo. We suggest that ADAM10 is a
mediator of PrP C … for PrP C . Furthermore, identification of ADAM10 as the sheddase of PrP …
mediator of PrP C … for PrP C . Furthermore, identification of ADAM10 as the sheddase of PrP …