User profiles for D. J. Clegg

Deborah Clegg

Cedars-Sinai Medical Center
Verified email at cshs.org
Cited by 25845

The role of estrogens in control of energy balance and glucose homeostasis

F Mauvais-Jarvis, DJ Clegg, AL Hevener - Endocrine reviews, 2013 - academic.oup.com
Estrogens play a fundamental role in the physiology of the reproductive, cardiovascular,
skeletal, and central nervous systems. In this report, we review the literature in both rodents and …

The sexual dimorphism of obesity

BF Palmer, DJ Clegg - Molecular and cellular endocrinology, 2015 - Elsevier
The NIH has recently highlighted the importance of sexual dimorphisms and has mandated
inclusion of both sexes in clinical trials and basic research. In this review we highlight new …

Obesity and cancer—mechanisms underlying tumour progression and recurrence

J Park, TS Morley, M Kim, DJ Clegg… - Nature Reviews …, 2014 - nature.com
Over the past several years, the field of cancer research has directed increased interest
towards subsets of obesity-associated tumours, which include mammary, renal, oesophageal, …

[HTML][HTML] Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

…, TA Knotts, G Shui, DJ Clegg… - The Journal of …, 2011 - Am Soc Clin Investig
Obesity is associated with an enhanced inflammatory response that exacerbates insulin
resistance and contributes to diabetes, atherosclerosis, and cardiovascular disease. One …

Gonadal hormones determine sensitivity to central leptin and insulin

DJ Clegg, LM Brown, SC Woods, SC Benoit - Diabetes, 2006 - Am Diabetes Assoc
Males have proportionally more visceral fat and are more likely to develop complications
associated with obesity than females, and the male brain is relatively more sensitive to the …

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

KA Posey, DJ Clegg, RL Printz… - American Journal …, 2009 - journals.physiology.org
Weight gain induced by an energy-dense diet is hypothesized to arise in part from defects in
the neuronal response to circulating adiposity negative feedback signals, such as insulin. …

[PDF][PDF] Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction

…, LD Hahner, SA Khan, CF Elias, JK Elmquist, DJ Clegg - Cell metabolism, 2011 - cell.com
Estrogens regulate body weight and reproduction primarily through actions on estrogen
receptor-α (ERα). However, ERα-expressing cells mediating these effects are not identified. We …

Silencing of estrogen receptor α in the ventromedial nucleus of hypothalamus leads to metabolic syndrome

…, CV Mobbs, XJ Yang, DJ Clegg… - Proceedings of the …, 2007 - National Acad Sciences
Estrogen receptor α (ERα) plays a pivotal role in the regulation of food intake and energy
expenditure by estrogens. Although it is well documented that a disruption of ERα signaling in …

The catabolic action of insulin in the brain is mediated by melanocortins

…, R Strauss, A Jackman, DJ Clegg… - Journal of …, 2002 - Soc Neuroscience
Like leptin, the pancreatic hormone insulin is an important adiposity signal to the brain. We
report that the hypothalamic melanocortin system is an important target of the actions of …

Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia

KD Niswender, CD Morrison, DJ Clegg, R Olson… - Diabetes, 2003 - Am Diabetes Assoc
In peripheral tissues, insulin signaling involves activation of the insulin receptor substrate (IRS)-phosphatidylinositol
3-kinase (PI3K) enzyme system. In the hypothalamus, insulin …