… Mulkey et al. (44) recently proposed a similar hypothesis, explaining, in part, hyperoxic …
The three main findings in the study of Mulkey et al. (44) were as follows. 1) Not all neurons …

… Data shown in A are redrawn from Dean and Mulkey (58). B: the interface brain slice is
maintained at the fluid-gas interface of the perfusate and warmed and humidified 95% O 2 + 5% …

The rat retrotrapezoid nucleus (RTN) contains about 2000 Phox2b-expressing glutamatergic
neurons (ccRTN neurons; 800 in mice) with a well-understood developmental lineage. …

A long-standing theory posits that central chemoreception, the CNS mechanism for CO 2
detection and regulation of breathing, involves neurons located at the ventral surface of the …

Central congenital hypoventilation syndrome is caused by mutations of the gene that encodes
the transcription factor Phox2b. The syndrome is characterized by a severe form of sleep …

The rat retrotrapezoid nucleus (RTN) contains neurons described as central
chemoreceptors in the adult and respiratory rhythm-generating pacemakers in neonates [parafacial …

… would have to be relatively insensitive to TEA, because we found only a small decrement
in pH sensitivity of RTN neurons when the perfusate included up to 40 mm TEA (Mulkey and …

Serotonin activates respiration and enhances the stimulatory effect of CO 2 on breathing.
The present study tests whether the mechanism involves the retrotrapezoid nucleus (RTN), a …

… However, RTN astrocytes are not responsive to norepinephrine or serotonin (DK Mulkey,
unpublished observations), suggesting the effects of desipramine on these cells is mediated by …

Key points • The retrotrapezoid nucleus (RTN) is an important site of chemoreception, ie the
mechanism by which the brain regulates breathing in response to changes in tissue CO 2 /H …