User profiles for E. Hawrot

Edward Hawrot

Brown University
Verified email at brown.edu
Cited by 3671

Amino acid sequence similarity between rabies virus glycoprotein and snake venom curaremimetic neurotoxins

TL Lentz, PT Wilson, E Hawrot, DW Speicher - Science, 1984 - science.org
Evidence was presented earlier that a host-cell receptor for the highly neurotropic rabies
virus might be the acetylcholine receptor. The amino acid sequence of the glycoprotein of …

Proteomic analysis of an α7 nicotinic acetylcholine receptor interactome

JA Paulo, WJ Brucker, E Hawrot - Journal of proteome research, 2009 - ACS Publications
The α7 nicotinic acetylcholine receptor (nAChR) is well established as the principal high-affinity
α-bungarotoxin-binding protein in the mammalian brain. We isolated carbachol-sensitive …

The metabotropic GABA receptor: molecular insights and their functional consequences

S Blein, E Hawrot*, P Barlow - Cellular and Molecular Life Sciences CMLS, 2000 - Springer
Recent years have seen rapid and significant advances in our understanding of the G-protein-coupled
γ-amino butyric acid, B-type (GABA B ) receptor, which could be a therapeutic …

Synthetic peptides corresponding to sequences of snake venom neurotoxins and rabies virus glycoprotein bind to the nicotinic acetylcholine receptor

TL Lentz, E Hawrot, PT Wilson - Proteins: Structure, Function …, 1987 - Wiley Online Library
Peptides corresponding to portions of loop 2 of snake venom curare‐mimetic neurotoxins
and to a structually similar region of rabies virus glycoprotein were synthesized. Interaction of …

Membrane assembly: movement of phosphatidylserine between the cytoplasmic and outer membranes of Escherichia coli

KE Langley, E Hawrot, EP Kennedy - Journal of bacteriology, 1982 - Am Soc Microbiol
Phosphatidylserine, normally a trace phospholipid in Escherichia coli, accumulates at high
levels in temperature-sensitive phosphatidylserine decarboxylase mutants at nonpermissive …

[53] Long-term culture of dissociated sympathetic neurons

E Hawrot, PH Patterson - Methods in enzymology, 1979 - Elsevier
Publisher Summary This chapter discusses long-term primary culture of dissociated neurons,
a technique that proved to be a valuable tool in studies of neuronal development and …

Binding, internalization, and retrograde transport of 125I-nerve growth factor in cultured rat sympathetic neurons

P Claude, E Hawrot, DA Dunis… - Journal of …, 1982 - Soc Neuroscience
… Similar results were obtained when binding was carried out at 1C a condition in which
endocytosis is curtailed and only true surface binding is measured (E. Hawrot, unpublished …

[HTML][HTML] α7 Nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension

…, I Polina, MW Cypress, BS Jhun, E Hawrot… - JCI insight, 2021 - ncbi.nlm.nih.gov
… (E) Quantitated immunofluorescence intensity of α7 nAChR in nonpermeabilized isolated
RVCF from 7-wk control and PH animals. (F) Summary schematic. Data are shown as mean ± …

Phospholipid composition and membrane function in phosphatidylserine decarboxylase mutants of Escherichia coli.

E Hawrot, EP Kennedy - Journal of Biological Chemistry, 1978 - ASBMB
… A similar study of genetically produced alterations in the polar groups of E. coli membrane
… in Medium E (21) by plating diluted samples on plates of supplemented Medium E. Colony …

[PDF][PDF] Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor

GF Tomaselli, JT McLaughlin, ME Jurman, E Hawrot… - Biophysical journal, 1991 - cell.com
… Preston-Hurlburt, and E. Hawrot. 1990. The role of tyrosine at the ligand-binding site of
the … Hawrot. 1985. Determination of the primary amino acid sequence specifying the a-…