Amperometry is widely used to study exocytosis of neurotransmitters and hormones in
various cell types. Analysis of the shape of the amperometric spikes that originate from the …

The most striking morphologic change in neurons during normal aging is the accumulation of
autophagic vacuoles filled with lipofuscin or neuromelanin pigments. These organelles are …

… (E) of the redox partners. As the electron transfer is often followed by irreversible reactions,
E … at different rates, which yield E=0.75 V for DAQ/DA (DAQ+2 H + +2 e − ⇄DA). At pH 7.4 the …

The basis for selective death of specific neuronal populations in neurodegenerative
diseases remains unclear. Parkinson's disease (PD) is a synucleinopathy characterized by a …

Altered degradation of α-synuclein (α-syn) has been implicated in the pathogenesis of
Parkinson disease (PD). We have shown that α-syn can be degraded via chaperone-mediated …

α-Synuclein (α-syn), a protein implicated in Parkinson's disease pathogenesis, is a
presynaptic protein suggested to regulate transmitter release. We explored how α-syn …

Homocysteine is a key junction metabolite in methionine metabolism. It suffers two major
metabolic fates: transmethylation catalyzed by methionine synthase or betaine homocysteine …

… (E) LC catecholamine axon density is significantly greater than the density of VTA
dopamine axons in the dorsal hippocampus (LC: 32.53 ± 5.48%, VTA: 7.20 ± 1.32%, Mann–Whitney …

Components of the proteostasis network malfunction in aging, and reduced protein quality
control in neurons has been proposed to promote neurodegeneration. Here, we investigate …

mTOR is a regulator of cell growth and survival, protein synthesis-dependent synaptic
plasticity, and autophagic degradation of cellular components. When triggered by mTOR …