Methamphetamine and methcathinone are psychostimulant drugs with high potential for abuse.
In animals, methamphetamine and related drugs are known to damage brain dopamine (…

Aripiprazole (OPC 14597) is an antipsychotic drug that has high affinity for dopamine D 2
and D 3 receptors and the dopamine autoreceptor. It is being developed for treatment of …

OBJECTIVE: Dopaminergic abnormalities in frontal-subcortical circuits have been hypothesized
as the underlying pathophysiologic mechanism in Tourette’s syndrome. The objective of …

… (F) KO mice had significantly more primary dendrites. … ANOVA results indicated a
significant interaction between genotype and trial [F (5, 100) = 3.23, P ≤ 0.01; Fig. 3A]. Post hoc …

A column-switch high performance liquid chromatography method for the analysis of 4 mL
of plasma is described with six examples of chromatography of [ 11 C]-labeled positron-…

Dopamine (DA) deficiency has been implicated in Lesch-Nyhan disease (LND), a genetic
disorder that is characterized by hyperuricemia, choreoathetosis, dystonia, and compulsive self…

… fore- and hindpaws showed a sex and genotype interaction of significance [F(1,28) = 3.62, P
= 0.067; Fig… Female (F) mutant mice did not differ in DA, DOPAC, and HVA levels. *P < 0.05. …

Dystonia is a neurological disorder characterized by abnormal involuntary movements that
are prolonged and often cause twisting and turning. Several genetically modified worms, fruit …

Infectious diseases are caused by the invasion of pathogens into a host. To explore the
mechanisms of pathogen infections and cellular responses, human models that can accurately …

Calmodulin is a ubiquitous Ca 2+ sensor molecule encoded by three distinct calmodulin
genes, CALM1–3. Recently, mutations in CALM1–3 have been reported to be associated with …