Stroke is a major cause of death and disability worldwide. Yet therapeutic strategies available
to treat stroke are very limited. There is an urgent need to develop novel therapeutics that …

Background Neuroprotection for ischemic stroke is a growing field, built upon the elucidation
of the biochemical pathways of ischemia first studied in the 1970s. Beginning in the early …

This review highlights the multifunctional properties of perlecan (HSPG2) and its potential
roles in repair biology. Perlecan is ubiquitous, occurring in vascular, cartilaginous, adipose, …

Heterozygous mutation or deletion of the ß subunit of platelet-activating factor acetylhydrolase
(PAFAH1B1, also known as LIS1) in humans is associated with type I lissencephaly, a …

Neurological manifestations are a significant complication of coronavirus disease (COVID-19),
but underlying mechanisms aren’t well understood. The development of animal models …

Stroke is the leading cause of long-term disability and the third leading cause of death in the
United States. While most research thus far has focused on acute stroke treatment and …

… Bix was supported by Tulane University startup funds. Dr. Bix is the inventor on a filed
provisional patent with the USPTO related to this work. All other authors have reported that they …

… Address for reprint requests and other correspondence: GJ Bix, University of Kentucky
800 S. Limestone 430 Sanders-Brown Center on Aging Lexington, KY 40536 (e-mail: [email …

Therapeutic angiogenesis has long been considered a viable treatment for vasculature
disruptions, including cerebral vasculature diseases. One widely-discussed treatment method to …

The cerebral microvasculature is important for maintaining brain homeostasis. This is achieved
via the blood-brain barrier (BBB), composed of endothelial cells with specialized tight …