The most characteristic feature of microglial cells is their rapid activation in response to even
minor pathological changes in the CNS. Microglia activation is a key factor in the defence of …

Microglia form a regularly spaced network of resident glial cells throughout the central nervous
system (CNS). They are morphologically, immunophenotypically and functionally related …

… G., and Kreutzberg. GW 11991b) Respiratory burst in brain macrophages: A flow cytometric
… Gottmann, K., Hanati, R., and Kreutzberg, GW (19901 Cultured microglia cells have a distinct …

The seven-transmembrane receptor CX 3 CR1 is a specific receptor for the novel CX 3 C
chemokine fractalkine (FKN)(neurotactin). In vitro data suggest that membrane anchoring of …

The present review summarizes recently acquired data in vivo, which support a role of CNS
microglia as a source of defense cells in the CNS capable of carrying out certain immune …

Damage to the central nervous system (CNS) leads to cellular changes not only in the affected
neurons but also in adjacent glial cells and endothelia, and frequently, to a recruitment of …

THE period of natural cell death in the development of rodent motor neurons is followed by a
period of sensitivity to axonal injury 1-3 . In the rat this early postnatal period of vulnerability …

This study identifies by microautoradiography activated microglia/macrophages as the main
cell type expressing the peripheral benzodiazepine binding site (PBBS) at sites of active …

Gene therapy in the central nervous system (CNS) is hindered by the presence of the blood–brain
barrier, which restricts access of serum constituents and peripheral cells to the brain …

CILIARY neurotrophic factor (CNTF) supports the survival of embryonic motor neurons in vitro
1,2 and in vivo 3 , and prevents lesion-mediated degeneration of rat motor neurons during …