User profiles for H. C. Hemmings
Hugh HemmingsWeill Cornell Medical College Verified email at med.cornell.edu Cited by 15206 |
Emerging molecular mechanisms of general anesthetic action
General anesthetics are essential to modern medicine, and yet a detailed understanding of
their mechanisms of action is lacking. General anesthetics were once believed to be ‘drugs …
their mechanisms of action is lacking. General anesthetics were once believed to be ‘drugs …
Are anaesthetics toxic to the brain?
AE Hudson, HC Hemmings Jr - British journal of anaesthesia, 2011 - academic.oup.com
It has been assumed that anaesthetics have minimal or no persistent effects after emergence
from anaesthesia. However, general anaesthetics act on multiple ion channels, receptors, …
from anaesthesia. However, general anaesthetics act on multiple ion channels, receptors, …
Towards a comprehensive understanding of anesthetic mechanisms of action: a decade of discovery
Significant progress has been made in the 21st century towards a comprehensive
understanding of the mechanisms of action of general anesthetics, coincident with progress in …
understanding of the mechanisms of action of general anesthetics, coincident with progress in …
DARPP-32, a dopamine-and adenosine 3': 5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical …
CC Ouimet, PE Miller, HC Hemmings… - Journal of …, 1984 - Soc Neuroscience
Immunocytochemical studies have been carried out to determine the regional and cellular
distribution of DARPP-32, a protein the phosphorylation of which can be regulated by …
distribution of DARPP-32, a protein the phosphorylation of which can be regulated by …
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1
The neurotransmitter dopamine has been demonstrated by biochemical 1 , histochemical 2
and immunocytochemical 3,4 techniques to be unevenly distributed in the mammalian …
and immunocytochemical 3,4 techniques to be unevenly distributed in the mammalian …
Modulation of calcium currents by a D1 dopaminergic protein kinase/phosphatase cascade in rat neostriatal neurons
In rat neostriatal neurons, D1 dopamine receptors regulate the activity of cyclic AMP-dependent
protein kinase (PKA) and protein phosphatase 1 (PP1). The influence of these signaling …
protein kinase (PKA) and protein phosphatase 1 (PP1). The influence of these signaling …
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons
The physiological state of the cell is controlled by signal transduction mechanisms which
regulate the balance between protein kinase and protein phosphatase activities 1 . Here we …
regulate the balance between protein kinase and protein phosphatase activities 1 . Here we …
Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar
…, L Vutskits, Z Xie, HC Hemmings Jr - British journal of …, 2013 - academic.oup.com
Although previously considered entirely reversible, general anaesthesia is now being viewed
as a potentially significant risk to cognitive performance at both extremes of age. A large …
as a potentially significant risk to cognitive performance at both extremes of age. A large …
Phytochemicals perturb membranes and promiscuously alter protein function
…, K Hall, T Maretzky, HC Hemmings Jr… - ACS chemical …, 2014 - ACS Publications
A wide variety of phytochemicals are consumed for their perceived health benefits. Many of
these phytochemicals have been found to alter numerous cell functions, but the mechanisms …
these phytochemicals have been found to alter numerous cell functions, but the mechanisms …
DARPP-32, a dopamine-and adenosine 3': 5'-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. II. Purification and …
HC Hemmings, AC Nairn, DW Aswad… - Journal of …, 1984 - Soc Neuroscience
… caudate nucleus immunoprecipitated phosphorylated DARPP-32 from rat caudatoputamen,
and that rat DARPP-32 cross-reacted with bovine DARPP-32 in a radioimmunoassay (HC …
and that rat DARPP-32 cross-reacted with bovine DARPP-32 in a radioimmunoassay (HC …