Senile plaques and neurofibrillary tangles, the two hallmark lesions of Alzheimer's disease,
are the results of the pathological deposition of proteins normally present throughout the …

… To this end, double-transgenic mice containing the entire human TAU gene on the mouse
TAU −/− background were created to only express human tau proteins (HN Dawson et al., …

Amyloid β (Aβ) and tau protein are both implicated in memory impairment, mild cognitive
impairment (MCI), and early Alzheimer's disease (AD), but whether and how they interact is …

Abstract Analysis of brain microtubule protein from patients with Alzheimer’s disease showed
decreased alpha tubulin levels along with increased acetylation of the alpha tubulin subunit…

Pathological evidence for selective four-repeat (4R) tau deposition in certain dementias and
exon 10-positioned MAPT mutations together suggest a 4R-specific role in causing disease. …

A central issue in the pathogenesis of tauopathy is the question of how tau protein dysfunction
leads to neurodegeneration. We have previously demonstrated that the absence of tau …

Female sex is associated with improved outcome in experimental brain injury models, such
as traumatic brain injury, ischemic stroke, and intracerebral hemorrhage. This implies female …

Unicellular green algae, like Chlorella, offer a potentially useful system for the expression of
heterologous proteins. However, the development of Chlorella as a bioreactor has been …

Cognitive impairment is common following traumatic brain injury (TBI), and neuroinflammatory
mechanisms may predispose to the development of neurodegenerative disease. …

… Hana Dawson’s research interests are focused on the role of tau protein in neurodegenerative
disorders involving deposition of abnormal tau protein isoforms in neurons and glial cells …