User profiles for H. Kiem

Hans-Peter Kiem

Fred Hutchinson Cancer Center
Verified email at fredhutch.org
Cited by 24716

International AIDS Society global scientific strategy: towards an HIV cure 2016

…, G Henderson, TJ Henrich, R Jefferys, HP Kiem… - Nature medicine, 2016 - nature.com
Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …

[PDF][PDF] SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues

…, HB Schiller, LE Zaragosi, P Barbry, A Leslie, HP Kiem… - Cell, 2020 - cell.com
There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…

[PDF][PDF] Hematopoietic-stem-cell-based gene therapy for HIV disease

HP Kiem, KR Jerome, SG Deeks, JM McCune - Cell stem cell, 2012 - cell.com
Although combination antiretroviral therapy can dramatically reduce the circulating viral load
in those infected with HIV, replication-competent virus persists. To eliminate the need for …

Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts

…, L Pabon, H Reinecke, EA Gill, V Nelson, HP Kiem… - Nature, 2014 - nature.com
… e–h, Frequency of arrhythmias is highest within the first 2 weeks after hESC-CM … or AIVR
for more than 18 h per 24 h period). NSAIVR, non-sustained accelerated idioventricular rhythm. …

Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus-tumor effects

…, GE Georges, FC Grumet, HP Kiem… - Blood, The Journal …, 2001 - ashpublications.org
Toxicities have limited the use of allogeneic hematopoietic cell transplantation (HCT) to
younger, medically fit patients. In a canine HCT model, a combination of postgrafting …

Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity.

IG Schmidt-Wolf, RS Negrin, HP Kiem… - The Journal of …, 1991 - rupress.org
… at -20C for at least 20 h. Sections were stained either with … intravenously into SCID mice
3-48 h after irradiation. 10 U/ml … into two equal doses and injected 24 h apart. Animals were …

Stable mixed hematopoietic chimerism in DLA-identical littermate dogs given sublethal total body irradiation before and pharmacological immunosuppression after …

…, HP Kiem, W Leisenring, H Shulman - Blood, The Journal …, 1997 - ashpublications.org
Postgrafting cyclosporine (CSP) given for 35 days resulted in establishment of stable marrow
grafts from DLA-identical canine littermates after otherwise suboptimal, but nevertheless, …

Comparative analysis of risk factors for acute graft-versus-host disease and for chronic graft-versus-host disease according to National Institutes of Health consensus …

…, PA Carpenter, SJ Lee, HP Kiem… - Blood, The Journal …, 2011 - ashpublications.org
Risk factors for grades 2-4 acute graft-versus-host disease (GVHD) and for chronic GVHD as
defined by National Institutes of Health consensus criteria were evaluated and compared in …

Chimeric antigen receptor T-cell approaches to HIV cure

…, CW Peterson, HP Kiem - Current Opinion in HIV and …, 2018 - journals.lww.com
Despite promising results in preclinical studies, only a handful of clinical trials have been
initiated worldwide. Several obstacles remain prior to successful application of HIV-specific …

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

…, M Ngom, S Imren, DC Roy, KL Watts, HP Kiem… - Science, 2014 - science.org
The small number of hematopoietic stem and progenitor cells in cord blood units limits their
widespread use in human transplant protocols. We identified a family of chemically related …