The introduction of two transgenes into one animal is increasingly common as transgenic
experiments become more sophisticated. In this study we examine two strategies for creating …

Mutations in the presenilin 1 (PS1) and presenilin 2 genes cosegregate with the majority of
early-onset familial Alzheimer's disease (FAD) pedigrees. We now document that the Aβ1–42…

The majority of early-onset cases of familial Alzheimer's disease (FAD) are linked to mutations
in two related genesPS1 and PS2, located on chromosome 14 and 1, respectively. Using …

In several pedigrees of early onset familial Alzheimer’s disease (FAD), point mutations in the
(I-amyloid precursor protein (APP) gene are genetically linked to the disease. This finding …

Huntington's disease (HD) is an inherited, neurodegenerative disorder caused by the expansion
of a glutamine repeat in the N-terminus of the huntingtin protein. To gain insight into the …

… Cultures were harvested immediately or 24 h later, before … After an additional 24 h, the cells
were labeled as described … proteins collected at 0 h and 24 h after labeling. The entirety of …

Epidemiological studies suggest that individuals with greater education or more cognitively
demanding occupations have diminished risk of developing dementia. We wanted to test …

Alzheimer's disease is characterized by the presence of senile plaques comprised primarily
of deposits of the beta-amyloid protein (A beta) derived from larger amyloid precursor …

Overexpression of the gene encoding the β–amyloid precursor protein (APP) may have a key
role in the pathogenesis of both Alzheimer's disease (AD) and Down Syndrome (DS). We …

An expression plasmid (MoPrP.Xho), for use in transgenic mice, was developed from the
promoter, 5′ intronic, and 3′ untranslated sequences of the murine prion protein gene. …