The extensive lengths of neuronal processes necessitate efficient mechanisms for communication
with the cell body. Neuronal regeneration after nerve injury requires new transcription; …

Neuronal regeneration in the peripheral nervous system requires mobilization of intrinsic
neurite outgrowth mechanisms. This process depends on retrograde signaling between lesion …

Retrograde axonal injury signalling stimulates cell body responses in lesioned peripheral
neurons. The involvement of importins in retrograde transport suggests that transcription …

How is protein synthesis initiated locally in neurons? We found that mTOR (mechanistic
target of rapamycin) was activated and then up-regulated in injured axons, owing to local …

Subcellular localization of mRNA enables compartmentalized regulation within large cells.
Neurons are the longest known cells; however, so far, evidence is lacking for an essential …

Retrograde signaling from axon to soma activates intrinsic regeneration mechanisms in
lesioned peripheral sensory neurons; however, the links between axonal injury signaling and …

Neurons exhibit great size differences, and must coordinate biosynthesis rates in cell bodies
with the growth needs of different lengths of axons. Classically, axon growth has been …

How can cells sense their own size to coordinate biosynthesis and metabolism with their
growth needs? We recently proposed a motor-dependent bidirectional transport mechanism for …

How is neuropathic pain regulated in peripheral sensory neurons? Importins are key regulators
of nucleocytoplasmic transport. In this study, we found that importin α3 (also known as …

Nucleolin is a multifunctional RNA Binding Protein (RBP) with diverse subcellular localizations,
including the nucleolus in all eukaryotic cells, the plasma membrane in tumor cells, and …