Evidence accumulated over more than two decades has implicated Ca 2+ dysregulation in
brain aging and Alzheimer's disease (AD), giving rise to the Ca 2+ hypothesis of brain aging …

Astrocytes are the most abundant cell type in the brain and play a critical role in maintaining
healthy nervous tissue. In Alzheimer's disease (AD) and most other neurodegenerative …

Age-dependent changes in multiple Ca 2+ -related electrophysiological processes in the
hippocampus appear to be consistent biomarkers of aging, and several also correlate with …

Multiple hippocampal processes and cognitive functions change with aging or Alzheimer's
disease, but the potential triggers of these aging cascades are not well understood. Here, we …

It has been recognized for some time that the Ca 2+ -dependent slow afterhyperpolarization
(sAHP) is larger in hippocampal neurons of aged compared with young animals. In addition, …

Neuroscientists studying normal brain aging, spinal cord injury, Alzheimer's disease (AD)
and other neurodegenerative diseases have focused considerable effort on carefully …

Purpose: Clinically, perturbations in the semaphorin signaling system have been associated
with autism and epilepsy. The semaphorins have been implicated in guidance, migration, …

Peripheral insulin resistance is a key component of metabolic syndrome associated with
obesity, dyslipidemia, hypertension, and type 2 diabetes. While the impact of insulin resistance …

Brain Ca 2+ regulatory processes are altered during aging, disrupting neuronal, and
cognitive functions. In hippocampal pyramidal neurons, the Ca 2+ -dependent slow …

With aging, multiple Ca 2+ -associated electrophysiological processes exhibit increased
magnitude in hippocampal pyramidal neurons, including the Ca 2+ -dependent slow …