User profiles for J. M. LaSalle
Janine M. LaSalleProfessor of Microbiology and Immunology, UC Davis Verified email at ucdavis.edu Cited by 11648 |
The comorbidity of autism with the genomic disorders of chromosome 15q11. 2-q13
A Hogart, D Wu, JM LaSalle, NC Schanen - Neurobiology of disease, 2010 - Elsevier
A cluster of low copy repeats on the proximal long arm of chromosome 15 mediates various
forms of stereotyped deletions and duplication events that cause a group of …
forms of stereotyped deletions and duplication events that cause a group of …
Small-magnitude effect sizes in epigenetic end points are important in children's environmental health studies: the children's environmental health and disease …
…, J Herbstman, N Holland, JM LaSalle… - Environmental …, 2017 - ehp.niehs.nih.gov
Background: Characterization of the epigenome is a primary interest for children’s
environmental health researchers studying the environmental influences on human populations, …
environmental health researchers studying the environmental influences on human populations, …
[HTML][HTML] Exploring the evidence for epigenetic regulation of environmental influences on child health across generations
Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …
influences that may impact health outcomes directly or via interactions with the genome or …
Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3
RC Samaco, A Hogart, JM LaSalle - Human molecular genetics, 2005 - academic.oup.com
Autism is a common neurodevelopmental disorder of complex genetic etiology. Rett syndrome,
an X-linked dominant disorder caused by MECP2 mutations, and Angelman syndrome, …
an X-linked dominant disorder caused by MECP2 mutations, and Angelman syndrome, …
Integrated epigenomic analyses of neuronal MeCP2 reveal a role for long-range interaction with active genes
…, PJ Farnham, JM LaSalle - Proceedings of the …, 2007 - National Acad Sciences
Mutations in MECP2 cause the autism-spectrum disorder Rett syndrome. MeCP2 is
predicted to bind to methylated promoters and silence transcription. However, the first large-scale …
predicted to bind to methylated promoters and silence transcription. However, the first large-scale …
Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation
…, A Hogart, Y Gwye, MR Martin, JM LaSalle - Epigenetics, 2006 - Taylor & Francis
… Samaco RC, Nagarajan RP, Braunschweig D, LaSalle JM. Multiple pathways regulate MeCP2
expression in normal brain development and exhibit defects in autism-spectrum disorders…
expression in normal brain development and exhibit defects in autism-spectrum disorders…
The human placenta methylome
…, I Korf, WP Robinson, JM LaSalle - Proceedings of the …, 2013 - National Acad Sciences
Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but
also over larger genomic regions. In most human tissues, the vast majority of the genome is …
also over larger genomic regions. In most human tissues, the vast majority of the genome is …
Rett syndrome astrocytes are abnormal and spread MeCP2 deficiency through gap junctions
…, S Swanberg, D Harvey, JM LaSalle… - Journal of …, 2009 - Soc Neuroscience
MECP2, an X-linked gene encoding the epigenetic factor methyl-CpG-binding protein-2, is
mutated in Rett syndrome (RTT) and aberrantly expressed in autism. Most children affected …
mutated in Rett syndrome (RTT) and aberrantly expressed in autism. Most children affected …
RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein
R Mizuta, JM LaSalle, HL Cheng… - Proceedings of the …, 1997 - National Acad Sciences
The human RAD51 protein is a homologue of the bacteria RecA and yeast RAD51 proteins
that are involved in homologous recombination and DNA repair. RAD51 interacts with …
that are involved in homologous recombination and DNA repair. RAD51 interacts with …
15q11-13 GABAA receptor genes are normally biallelically expressed in brain yet are subject to epigenetic dysregulation in autism-spectrum disorders
…, KA Patzel, DH Yasui, JM LaSalle - Human molecular …, 2007 - academic.oup.com
Human chromosome 15q11-13 is a complex locus containing imprinted genes as well as a
cluster of three GABA A receptor subunit (GABR) genes—GABRB3, GABRA5 and GABRG3. …
cluster of three GABA A receptor subunit (GABR) genes—GABRB3, GABRA5 and GABRG3. …