Glucocorticoids (GCs) are hormones released during the stress response that are well known
for their immunosuppressive and anti-inflammatory properties; however, recent advances …

Several neuropsychiatric diseases are related with stress (posttraumatic stress disorder, major
depressive disorder, anxiety disorders, schizophrenia) and stress exposure modifies the …

There is a growing awareness that gut commensal metabolites play a major role in host
physiology and indeed the pathophysiology of several illnesses. The composition of the …

Background— Stroke is the second to third leading cause of death. Toll-like receptor 4 (TLR4)
is a signaling receptor in innate immunity that is a specific immunologic response to …

BACKGROUND: Stressful challenges are associated with variations in immune parameters,
including increased innate immunity/inflammation. Among possible mechanisms through …

Background and Purpose— Psychological stress causes an inflammatory response in the
brain and is able to exacerbate brain damage caused by experimental stroke. We previously …

Background There is a pressing need to identify novel pathophysiological pathways relevant
to depression that can help to reveal targets for the development of new medications. Toll-…

Although the anti-inflammatory actions of glucocorticoids (GCs) are well established, evidence
has accumulated showing that proinflammatory GC effects can occur in the brain, in a …

Physical and psychological stresses are widely accepted as triggers and / or modifiers of
the clinical course of diverse gastrointestinal disorders such as peptic ulcer, irritable bowel …

The innate immunity is a stereotyped first line of defense against pathogens and unspecified
damage signals. One of main actors of innate immunity are the Toll-like receptors (TLRs), …