In 2003, the World Health Organization published a report on the global change in diet
resulting from industrialization, urbanization, and market globalization, and the impact on the …

Recent psychophysical and electrophysiological studies in humans suggest the existence of
two peripheral pathways for itch, one that is responsive to histamine and a second pathway …

Despite its clinical importance, the underlying neural mechanisms of itch sensation are
poorly understood. In many diseases, pruritus is not effectively treated with antihistamines, …

Morphine and surgical cingulotomy, or transection of the anterior cingulate cortex (ACC),
provides relief of chronic pain by selectively decreasing the affective dimension of the condition …

Objective Accumulation of mitochondrial DNA (mtDNA) damage has been associated with
aging and abnormal oxidative metabolism. We hypothesized that in human immunodeficiency …

In primates, C-fibre polymodal nociceptors are broadly classified into two groups based on
mechanosensitivity. Here we demonstrate that mechanically sensitive polymodal nociceptors …

The μ-opioid receptor (MOR) plays a critical role in morphine analgesia and nociceptive
transmission. However, the physiological roles for endogenous MOR mechanisms in …

Men are typically reported to have higher pain thresholds than women. Gonadal hormones,
particularly testosterone for males, may contribute to this effect. This study tested whether …

Homeostasis, an organisms’ tendency to maintain a healthy balance of the physiological state
of the body, is necessary for survival. Hunger induces a motivational state to consume food…

Soy consumption is said to prevent or treat atherosclerosis, cancer, pain, and memory deficits,
but experimental and clinical evidence to support these claims are lacking. We used in …