… Kirsch J, Betz H: The postsynaplic localization of the glycine • … J Neurosci 1995, in press.
This paper describes a method to determine receptor packing densities in postsynaptic clusters …

… of a3 sequences from spinal cord RNA (Kuhse et al.,1990b). As the a3 subunit forms
strychnine-sensitive chloride channels upon expression in Xenopus oocytes (Kuhse et al., 1990b), …

The amino acids l-glutamate and glycine are essential agonists of the excitatory NMDA
receptor, a subtype of the ionotropic glutamate receptor family. The native NMDA receptor is …

NMDA receptors require both L-glutamate and the coagonist glycine for efficient channel
activation. The glycine binding site of these heteromeric receptor proteins is formed by regions …

Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein,
gephyrin. Molecular cloning revealed the similarity of gephyrin to prokaryotic and invertebrate …

Activation of the NMDA subtype of ionotropic glutamate receptors requires binding of both L-glutamate
and the coagonist glycine. Site-directed mutagenesis of the NMDARI (NRl) …

Scaffolding proteins underlying postsynaptic membrane specializations are important
structural and functional components of both excitatory and inhibitory synapses. At inhibitory …

… 735 736 C J … Magalei and J. Lorentz for technical assistance, and M. Baier and H. …
Laube hold Max-Planck postdoctoral fellowships, and J. Kirsch is the recipient of a Heisenberg …

The strychnine‐sensitive glycine receptor (GlyR) is a pentameric chloride channel protein
that exists in several developmentally and regionally regulated isoforms in the CNS. These …

… 1990a) and different al//-chimeric subunits were synthesized as described (Kuhse et al.
1993). For co-injection experiments, the al- and ,l-subunit cRNAs were mixed before injection to …