White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance
imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small …

BackgroundAnimal models of anxiety disorders emphasize the crucial role of locus ceruleus–noradrenergic
(norepinephrine, NE) signaling, the basolateral amygdala (BLA) and their …

See Whitwell (doi: 10.1093/brain/awy001 ) for a scientific commentary on this article. A
stereotypical anatomical propagation of tau pathology has been described in Alzheimer’s disease…

The human amygdala plays a pivotal role in the processing of socially significant information.
Anatomical studies show that the human amygdala is not a single homogeneous structure …

Introduction Diagnostic classification systems and guidelines posit distinguishing patterns of
impairment in Alzheimer’s (AD) and vascular dementia (VaD). In our study, we aim to …

The clinical heterogeneity of Alzheimer’s disease is not reflected in the rather diffuse cortical
deposition of amyloidß. We assessed the relationship between clinical symptoms, in vivo …

In a multimodal PET imaging approach, we determined the differential contribution of neurofibrillary
tangles (measured with [ 18 F] AV ‐1451) and beta‐amyloid burden (measured with [ …

Data is inconsistent concerning the question whether cognitive-physical training (CPT)
yields stronger cognitive gains than cognitive training (CT). Effects of additional counseling, …

An emerging theme in the neuroscience of emotion is the question of how acute stress
shapes, and distorts, social-emotional behavior. The prevailing neurocircuitry models of social-…

Neurodegenerative brain changes can affect the functional connectivity strength between
nodes of the default-mode network (DMN), which may underlie changes in cognitive …