User profiles for J. Louvel

Julien Louvel

Assistant professor of Medicinal Chemistry, Leiden University
Verified email at lacdr.leidenuniv.nl
Cited by 645

Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro

M Avoli, M D'Antuono, J Louvel, R Köhling… - Progress in …, 2002 - Elsevier
Seizures in patients presenting with mesial temporal lobe epilepsy result from the interaction
among neuronal networks in limbic structures such as the hippocampus, amygdala and …

Cellular and molecular mechanisms of epilepsy in the human brain

M Avoli, J Louvel, R Pumain, R Köhling - Progress in neurobiology, 2005 - Elsevier
Animal models have provided invaluable data for identifying the pathogenesis of epileptic
disorders. Clearly, the relevance of these experimental findings would be strengthened by the …

Epileptiform activity induced by low extracellular magnesium in the human cortex maintained in vitro

M Avoli, C Drapeau, J Louvel, R Pumain… - Annals of Neurology …, 1991 - Wiley Online Library
Extracellular field potentials and [K + ] o were recorded in slices of human epileptogenic
neocortex maintained in vitro during perfusion with Mg 2+ ‐free artificial cerebrospinal fluid (…

GABAA receptor‐dependent synchronization leads to ictogenesis in the human dysplastic cortex

M D'antuono, J Louvel, R Köhling, D Mattia… - Brain, 2004 - academic.oup.com
Patients with Taylor’s type focal cortical dysplasia (FCD) present with seizures that are often
medically intractable. Here, we attempted to identify the cellular and pharmacological …

Predicting binding affinities for GPCR ligands using free-energy perturbation

EB Lenselink, J Louvel, AF Forti… - ACS …, 2016 - ACS Publications
The rapid growth of structural information for G-protein-coupled receptors (GPCRs) has led
to a greater understanding of their structure, function, selectivity, and ligand binding. …

Effects of gap junction blockers on human neocortical synchronization

S Gigout, J Louvel, H Kawasaki, M D'antuono… - Neurobiology of …, 2006 - Elsevier
Field potentials and intracellular recordings were obtained from human neocortical slices to
study the role of gap junctions (GJ) in neuronal network synchronization. First, we examined …

Long-term follow-up of aortic involvement in giant cell arteritis: a series of 48 patients

…, P Duhaut, E Primard, L Lahaxe, N Girszyn, JP Louvel… - Medicine, 2009 - journals.lww.com
To date, only a few series have analyzed the long-term outcome of giant cell arteritis (GCA)
patients with aortic involvement, which prompted us to conduct the current retrospective study…

Masking synchronous GABA‐mediated potentials controls limbic seizures

M Barbarosie, J Louvel, M D'Antuono, I Kurcewicz… - …, 2002 - Wiley Online Library
Purpose: We determined how CA3‐driven interictal discharges block ictal activity generated
in the entorhinal cortex during bath application of 4‐aminopyridine (4AP, 50 μM). Methods: …

[HTML][HTML] Immediate hypersensitivity to contrast agents: the French 5-year CIRTACI study

…, F Leynadier, A Lillo-Le-Louet, JP Louvel… - …, 2018 - thelancet.com
Background Iodinated and gadolinium-based contrast media (ICM; GBCM) induce immediate
hypersensitivity (IH) reactions. Differentiating allergic from non-allergic IH is crucial; allergy …

Extracellular free potassium and calcium during synchronous activity induced by 4‐aminopyridine in the juvenile rat hippocampus.

M Avoli, J Louvel, I Kurcewicz, R Pumain… - The Journal of …, 1996 - Wiley Online Library
1. Field potential recordings and measurements of the extracellular concentration of free K+
([K+]o) and Ca2+ ([Ca2+]o) were made during application of 4‐aminopyridine (4‐AP, 50 …