User profiles for L. J. Chandler

L. Judson Chandler

Professor of Neuroscience, Medical University of South Carolina
Verified email at musc.edu
Cited by 8097

Alcohol and the prefrontal cortex

K Abernathy, LJ Chandler, JJ Woodward - International review of …, 2010 - Elsevier
The prefrontal cortex occupies the anterior portion of the frontal lobes and is thought to be
one of the most complex anatomical and functional structures of the mammalian brain. Its …

Mechanisms of persistent neurobiological changes following adolescent alcohol exposure: NADIA consortium findings

FT Crews, DL Robinson, LJ Chandler… - Alcoholism: clinical …, 2019 - Wiley Online Library
The Neurobiology of Adolescent Drinking in Adulthood (NADIA) Consortium has focused on
the impact of adolescent binge drinking on brain development, particularly on effects that …

Adaptive plasticity of NMDA receptors and dendritic spines: implications for enhanced vulnerability of the adolescent brain to alcohol addiction

EP Carpenter-Hyland, LJ Chandler - Pharmacology Biochemistry and …, 2007 - Elsevier
It is now known that brain development continues into adolescence and early adulthood
and is highly influenced by experience-dependent adaptive plasticity during this time. …

Intermittent access to 20% ethanol induces high ethanol consumption in Long–Evans and Wistar rats

…, B Medina, KE Abernathy, LJ Chandler… - Alcoholism: Clinical …, 2008 - Wiley Online Library
Background: There has been some difficulty getting standard laboratory rats to voluntarily
consume large amounts of ethanol without the use of initiation procedures. It has previously …

[HTML][HTML] Chronic alcohol exposure alters behavioral and synaptic plasticity of the rodent prefrontal cortex

…, NN New, JT Gass, HC Becker, LJ Chandler - PloS one, 2012 - journals.plos.org
In the present study, we used a mouse model of chronic intermittent ethanol (CIE) exposure
to examine how CIE alters the plasticity of the medial prefrontal cortex (mPFC). In acute …

Mayaro virus disease: an emerging mosquito-borne zoonosis in tropical South America

…, AM Powers, CL Hice, LJ Chandler… - Clinical infectious …, 1999 - academic.oup.com
This report describes the clinical, laboratory, and epidemiological findings on 27 cases of
Mayaro virus (MV) disease, an emerging mosquito-borne viral illness that is endemic in rural …

[HTML][HTML] Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in …

…, R Yaxley, SB Floresco, LJ Chandler - …, 2014 - nature.com
The prefrontal cortex (PFC) is a brain region that is critically involved in cognitive function
and inhibitory control of behavior, and adolescence represents an important period of …

Chronic ethanol exposure potentiates NMDA excitotoxicity in cerebral cortical neurons

LJ Chandler, H Newsom, C Sumners… - Journal of …, 1993 - Wiley Online Library
The effect of acute and chronic ethanol exposure on excitotoxicity in cultured rat cerebral
cortical neurons was examined. Neuronal death was quantitated by measuring the …

[HTML][HTML] Dopamine modulates persistent synaptic activity and enhances the signal-to-noise ratio in the prefrontal cortex

S Kroener, LJ Chandler, PEM Phillips, JK Seamans - PloS one, 2009 - journals.plos.org
Background The importance of dopamine (DA) for prefrontal cortical (PFC) cognitive functions
is widely recognized, but its mechanisms of action remain controversial. DA is thought to …

[HTML][HTML] The plasticity of extinction: contribution of the prefrontal cortex in treating addiction through inhibitory learning

LJ Chandler, JT Gass - Frontiers in psychiatry, 2013 - frontiersin.org
Theories of drug addiction that incorporate various concepts from the fields of learning and
memory have led to the idea that classical and operant conditioning principles underlie the …