Hyperphosphorylation of tau in PHF
M Morishima-Kawashima, M Hasegawa, K Takio… - Neurobiology of …, 1995 - Elsevier
… ~Requests for reprints should be addressed to Maho Morishima-Kawashima, Ph.D. at
her present address: Center for Neurologic Diseases, Brigham and Women's Hospital, 221 …
her present address: Center for Neurologic Diseases, Brigham and Women's Hospital, 221 …
The ubiquitin–proteasome system and the autophagic–lysosomal system in Alzheimer disease
…, M Morishima-Kawashima… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
As neurons age, their survival depends on eliminating a growing burden of damaged,
potentially toxic proteins and organelles—a capability that declines owing to aging and disease …
potentially toxic proteins and organelles—a capability that declines owing to aging and disease …
Alzheimer's disease: β‐Amyloid protein and tau
M Morishima‐Kawashima… - Journal of neuroscience …, 2002 - Wiley Online Library
… Within the tangles, N-terminally processed tau was found to be ubiquitinated (Morishima-Kawashima
et al., 1993). These observations were the first showing that the degeneration-…
et al., 1993). These observations were the first showing that the degeneration-…
[HTML][HTML] Proline-directed and Non-proline-directed Phosphorylation of PHF-tau (∗)
M Morishima-Kawashima, M Hasegawa, K Takio… - Journal of Biological …, 1995 - ASBMB
To gain insight into the abnormal phosphorylation of PHF-tau, we have determined the
phosphorylation sites by identifying phosphopeptides by means of ion spray mass spectrometry …
phosphorylation sites by identifying phosphopeptides by means of ion spray mass spectrometry …
[HTML][HTML] Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.
M Hasegawa, M Morishima-Kawashima, K Takio… - Journal of Biological …, 1992 - Elsevier
Tau with unusually slow mobilities in sodium dodecyl sulfate-polyacrylamide gel
electrophoresis was purified from the Sarkosyl-insoluble pellet of Alzheimer's disease brain …
electrophoresis was purified from the Sarkosyl-insoluble pellet of Alzheimer's disease brain …
γ-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of β-carboxyl terminal fragment
…, S Ishihara, M Morishima-Kawashima… - Journal of …, 2009 - Soc Neuroscience
… protease inhibitor mixture [0.5 mm diisopropylfluorophosphate (DIFP), 1 μg/ml … mm thiorphan,
5 mm phenanthroline, 100 μm bestatin, 10 μm amastatin, 0.1 μm arphamenine, and 5 mm …
5 mm phenanthroline, 100 μm bestatin, 10 μm amastatin, 0.1 μm arphamenine, and 5 mm …
Longer forms of amyloid β protein: implications for the mechanism of intramembrane cleavage by γ-secretase
Y Qi-Takahara, M Morishima-Kawashima… - Journal of …, 2005 - Soc Neuroscience
… inhibitors (0.1 mm diisopropyl fluorophosphate, 0.1 mm phenylmethylsulfonyl fluoride, 5
μg/… , 1 μg/ml amerstain, 5 mm 1,10-phenanthroline monohydrate, and 10 mm thiorphan). The …
μg/… , 1 μg/ml amerstain, 5 mm 1,10-phenanthroline monohydrate, and 10 mm thiorphan). The …
Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments
M Morishima-Kawashima, M Hasegawa, K Takio… - Neuron, 1993 - cell.com
We have investigated tibiquitinated paired helical filaments, which pro&e a proteinaceous
smear in ‘SDS-polyacrylamide gel electrophoresis and immunoblotting. The smear consisted …
smear in ‘SDS-polyacrylamide gel electrophoresis and immunoblotting. The smear consisted …
Oxidative stress induces intracellular accumulation of amyloid β-protein (Aβ) in human neuroblastoma cells
Several lines of evidence suggest that enhanced oxidative stress is involved in the pathogenesis
and/or progression of Alzheimer's disease (AD). Amyloid β-protein (Aβ) that composes …
and/or progression of Alzheimer's disease (AD). Amyloid β-protein (Aβ) that composes …
[HTML][HTML] In vivo phosphorylation sites in fetal and adult rat tau.
…, M Suzuki, K Takio, M Morishima-Kawashima… - Journal of Biological …, 1993 - Elsevier
Fetal tau and tau in paired helical filaments show similar immunoreactivities with several
phosphorylation-dependent paired helical filament-polyclonals and monoclonals, suggesting …
phosphorylation-dependent paired helical filament-polyclonals and monoclonals, suggesting …