User profiles for N. Šestan
Nenad SestanYale University Verified email at yale.edu Cited by 31007 |
Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex
The cerebral neocortex is segregated into six horizontal layers, each containing unique
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons and …
populations of molecularly and functionally distinct excitatory projection (pyramidal) neurons and …
[PDF][PDF] Evolution of the human nervous system function, structure, and development
The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …
most distinctive and impressive attributes. How the nervous system has changed in the …
New insights into the development of the human cerebral cortex
The cerebral cortex constitutes more than half the volume of the human brain and is presumed
to be responsible for the neuronal computations underlying complex phenomena, such …
to be responsible for the neuronal computations underlying complex phenomena, such …
De novo mutations revealed by whole-exome sequencing are strongly associated with autism
Multiple studies have confirmed the contribution of rare de novo copy number variations to
the risk for autism spectrum disorders 1 , 2 , 3 . But whereas de novo single nucleotide …
the risk for autism spectrum disorders 1 , 2 , 3 . But whereas de novo single nucleotide …
Spatio-temporal transcriptome of the human brain
Brain development and function depend on the precise regulation of gene expression.
However, our understanding of the complexity and dynamics of the transcriptome of the human …
However, our understanding of the complexity and dynamics of the transcriptome of the human …
Transcriptional landscape of the prenatal human brain
The anatomical and functional architecture of the human brain is mainly determined by prenatal
transcriptional processes. We describe an anatomically comprehensive atlas of the mid-…
transcriptional processes. We describe an anatomically comprehensive atlas of the mid-…
Sequence Variants in SLITRK1 Are Associated with Tourette's Syndrome
Tourette's syndrome (TS) is a genetically influenced developmental neuropsychiatric disorder
characterized by chronic vocal and motor tics. We studied Slit and Trk-like 1 (SLITRK1) as …
characterized by chronic vocal and motor tics. We studied Slit and Trk-like 1 (SLITRK1) as …
[HTML][HTML] Microarray analysis of microRNA expression in the developing mammalian brain
…, E Alvarez-Saavedra, M Townsend, A Yoshii, N Šestan… - Genome biology, 2004 - Springer
Background MicroRNAs are a large new class of tiny regulatory RNAs found in nematodes,
plants, insects and mammals. MicroRNAs are thought to act as post-transcriptional …
plants, insects and mammals. MicroRNAs are thought to act as post-transcriptional …
[HTML][HTML] Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism
Autism spectrum disorder (ASD) is a complex developmental syndrome of unknown etiology.
Recent studies employing exome- and genome-wide sequencing have identified nine high-…
Recent studies employing exome- and genome-wide sequencing have identified nine high-…
Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations
…, S Kumandaş, M Topçu, M Özmen, N Šestan… - Nature, 2010 - nature.com
The development of the human cerebral cortex is an orchestrated process involving the
generation of neural progenitors in the periventricular germinal zones, cell proliferation …
generation of neural progenitors in the periventricular germinal zones, cell proliferation …