Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example,
are highly active mediators with diverse biological activities. So far, proteinases have been …

… of this receptor family, now known to possess at least four members (PAR1–4), is the
novel mechanism of receptor triggering that involves the proteolytic unmasking of a cryptic N-…

Microorganisms colonize various ecological niches in the human habitat, as they do in
nature. Predominant forms of multicellular communities called biofilms colonize human tissue …

Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 and, by unknown
mechanisms, induce widespread inflammation. We found that a large proportion of primary spinal …

Mediators involved in the generation of symptoms in patients with irritable bowel syndrome (IBS)
are poorly understood. Here we show that colonic biopsy samples from IBS patients …

Using a combined pharmacological and gene-deletion approach, we have delineated a
novel mechanism of neurokinin-1 (NK-1) receptor-dependent hyperalgesia induced by …

… level of damage observed in rats given both celecoxib and SC-560 was caused by topical
irritant properties of celecoxib, we performed an additional experiment in which rats (n = 5 per …

Scientists who plan to publish in British Journal of Pharmacology (BJP) must read this article
before undertaking a study. This editorial provides guidance for the design of experiments. …

… the proteolytic cleavage of their N-terminal domain.1, 2, 3 The new N-terminal sequence that
… Values are mean ± SEM, n = 8 per group except for E where n = 6 per group. *, Significantly …

… The response to 10 nm capsaicin was … 10 nm) potentiated the response to capsaicin (100
nm) applied 5 min later by 53 ± 7% (n = 231 capsaicin-responsive neurons) and 88 ± 24% (n = …