User profiles for O. J. Becher
 | Oren BecherProfessor, Icahn School of Medicine at Mount Sinai Verified email at mssm.edu Cited by 8164 |
Pediatric high-grade glioma: biologically and clinically in need of new thinking
High-grade gliomas in children are different from those that arise in adults. Recent collaborative
molecular analyses of these rare cancers have revealed previously unappreciated …
molecular analyses of these rare cancers have revealed previously unappreciated …
Genetically engineered models have advantages over xenografts for preclinical studies
OJ Becher, EC Holland - Cancer research, 2006 - AACR
… If used intelligently as outlined in our review and exemplified in the case of imatinib, (Becher
and Holland, ref. 15) where the effect of imatinib on its target was shown as …
and Holland, ref. 15) where the effect of imatinib on its target was shown as …
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
Sequencing of pediatric gliomas has identified missense mutations Lys27Met (K27M) and
Gly34Arg/Val (G34R/V) in genes encoding histone H3.3 (H3F3A) and H3.1 (HIST3H1B). We …
Gly34Arg/Val (G34R/V) in genes encoding histone H3.3 (H3F3A) and H3.1 (HIST3H1B). We …
Cancer stem cells and survival pathways
Gliomas and medulloblastomas are the most frequent malignant brain tumors in adult and
children respectively. Although both tumors arise in the CNS, there is a significant difference …
children respectively. Although both tumors arise in the CNS, there is a significant difference …
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo
D Hambardzumyan, OJ Becher… - Genes & …, 2008 - genesdev.cshlp.org
Medulloblastomas are brain tumors that arise in the cerebellum of children and contain stem
cells in a perivascular niche thought to give rise to recurrence following radiation. We used …
cells in a perivascular niche thought to give rise to recurrence following radiation. We used …
Reasons for pediatrician nonadherence to asthma guidelines
Background The 1997 National Heart, Lung, and Blood Institute (NHLBI) asthma guidelines
include recommendations on how to improve the quality of care for asthma. Objective To …
include recommendations on how to improve the quality of care for asthma. Objective To …
Modeling adult gliomas using RCAS/t-va technology
…, NM Amankulor, KY Helmy, OJ Becher… - Translational …, 2009 - Elsevier
Malignant gliomas remain the most devastating childhood and adult tumors of the central
nervous system. Although adult and pediatric gliomas are histologically indistinguishable, they …
nervous system. Although adult and pediatric gliomas are histologically indistinguishable, they …
Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation
…, SM Pyonteck, OJ Becher… - Journal of …, 2009 - Soc Neuroscience
The adult mammalian brain responds to injury by activating a program of cell proliferation
during which many oligodendrocyte precursors, microglia, and some astrocytes proliferate. …
during which many oligodendrocyte precursors, microglia, and some astrocytes proliferate. …
Gli activity correlates with tumor grade in platelet-derived growth factor–induced gliomas
OJ Becher, D Hambardzumyan, EI Fomchenko… - Cancer research, 2008 - AACR
Gli signaling is critical for central nervous system development and is implicated in tumorigenesis.
To monitor Gli signaling in gliomas in vivo, we created platelet-derived growth factor–…
To monitor Gli signaling in gliomas in vivo, we created platelet-derived growth factor–…
Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma
OJ Becher, D Hambardzumyan, TR Walker, K Helmy… - Cancer research, 2010 - AACR
… Grant Support: OJ Becher is a St. Baldrick's scholar and is supported by Memorial Sloan-Kettering
Cancer Center Brain Tumor Center, Matthew Larson Foundation, and Witmer …
Cancer Center Brain Tumor Center, Matthew Larson Foundation, and Witmer …