User profiles for P. H. Reddy

P. Hemachandra Reddy

Texas Tech Health Sciences Center
Verified email at ttuhsc.edu
Cited by 30718

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

PH Reddy, MF Beal - Trends in molecular medicine, 2008 - cell.com
Recent studies of postmortem brains from Alzheimer's disease (AD) patients and transgenic
mouse models of AD suggest that oxidative damage, induced by amyloid β (Aβ), is …

[HTML][HTML] Mitochondrial dysfunction and oxidative stress in metabolic disorders—A step towards mitochondria based therapeutic strategies

JS Bhatti, GK Bhatti, PH Reddy - … et Biophysica Acta (BBA)-Molecular Basis …, 2017 - Elsevier
Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2 + regulation, reactive oxygen species …

Role of glutamate and NMDA receptors in Alzheimer's disease

R Wang, PH Reddy - Journal of Alzheimer's Disease, 2017 - content.iospress.com
Excitatory glutamatergic neurotransmission via N-methyl-d-aspartate receptor (NMDAR) is
critical for synaptic plasticity and survival of neurons. However, excessive NMDAR activity …

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease …

…, E Henson, BS Park, J Quinn, PH Reddy - Human molecular …, 2006 - academic.oup.com
… The extract was neutralized with 0.25 m Tris (pH 8.0) containing 30% acetonitrile and 5 m
NaOH before we used ELISA to determine the insoluble Aβ. For each sample, Aβ1–40 and Aβ1…

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease …

M Manczak, MJ Calkins, PH Reddy - Human molecular genetics, 2011 - academic.oup.com
… 0.1% sodium borohydrate solution dissolved in PBS at pH 8.0. We then washed the
sections three times for 5 min each, with PBS at pH 7.4. To block the endogenous peroxidase, …

Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

…, N Khullar, S Kumar, GK Bhatti, PH Reddy - Free Radical Biology …, 2022 - Elsevier
Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide. It is
characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia induced …

[HTML][HTML] Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease

S Pugazhenthi, L Qin, PH Reddy - … acta (BBA)-molecular basis of disease, 2017 - Elsevier
Cognitive decline in chronic diabetic patients is a less investigated topic. Diabetes and
obesity are among the modifiable risk factors for Alzheimer's disease (AD), the most common …

[HTML][HTML] Is Alzheimer's disease a type 3 diabetes? A critical appraisal

R Kandimalla, V Thirumala, PH Reddy - Biochimica et Biophysica Acta …, 2017 - Elsevier
Recently researchers proposed the term ‘Type-3-Diabetes’ for Alzheimer's disease (ad)
because of the shared molecular and cellular features among Type-1-Diabetes, Type-2-…

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of …

…, P Mao, U Shirendeb, PH Reddy - Human molecular …, 2011 - academic.oup.com
… immunocytochemical analysis of 6E10 (for Aβ), A11 (for Aβ oligomers) and cyclophilin D in
neurons from AβPP mice and WT mice using the method described in Calkins and Reddy (38)…

Mitochondria-targeted antioxidants protect against amyloid-β toxicity in Alzheimer's disease neurons

…, HH Szeto, B Park, PH Reddy - Journal of …, 2010 - content.iospress.com
The purpose of our study was to investigate the effects of the mitochondria-targeted antioxidants,
MitoQ and SS31, and the anti-aging agent resveratrol on neurons from a mouse model (…