Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic modulator
and also as a neuromodulator at the synaptic level. We will present evidence to suggest …

… release appears to be unrelated to the modification of cAMP levels (Cunha, 2001a). Given
that many of the steps in the signaling … Rebola and RA Cunha, unpublished observations). …

The functional role of heteromers of G-protein-coupled receptors is a matter of debate. In the
present study, we demonstrate that heteromerization of adenosine A 1 receptors (A 1 Rs) …

Adenosine is a neuromodulator that operates via the most abundant inhibitory adenosine A
1 receptors (A 1 Rs) and the less abundant, but widespread, facilitatory A 2A Rs. It is …

Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the central
nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory A 1 …

Adenosine A 2A receptors are highly enriched in the basal ganglia system. They are
predominantly expressed in enkephalin-expressing GABAergic striatopallidal neurons and …

With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to its …

Consumption of caffeine, an adenosine receptor antagonist, was found to be inversely
associated with the incidence of Alzheimer's disease. Moreover, caffeine protects cultured …

Alzheimer's disease (AD) is characterized by memory impairment, neurochemically by
accumulation of β-amyloid peptide (namely Aβ 1-42 ) and morphologically by an initial loss of …

The physiological conditions under which adenosine A 2A receptors modulate synaptic
transmission are presently unclear. We show that A 2A receptors are localized postsynaptically …