Amyloid β-degrading cryptidases: insulin degrading enzyme, presequence peptidase, and neprilysin
… Therapeutic intervention could occur by re-compartmentalization of cryptidases with gene
targeted ex vivo gene therapy [18]. As described above, the soluble form of neprilysin that was …
targeted ex vivo gene therapy [18]. As described above, the soluble form of neprilysin that was …
Structure, function, and regulation of insulin‐degrading enzyme
RE Hulse, LA Ralat, T Wei‐Jen - Vitamins & Hormones, 2009 - Elsevier
The short half‐life of insulin in the human body (4–6 min) prompted the search and discovery
of insulin‐degrading enzyme (IDE), a 110‐kDa metalloprotease that can rapidly degrade …
of insulin‐degrading enzyme (IDE), a 110‐kDa metalloprotease that can rapidly degrade …
Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain
…, R McGreevy, CA Villalba-Galea, RE Hulse… - Nature structural & …, 2014 - nature.com
The transduction of transmembrane electric fields into protein motion has an essential role in
the generation and propagation of cellular signals. Voltage-sensing domains (VSDs) carry …
the generation and propagation of cellular signals. Voltage-sensing domains (VSDs) carry …
Structure of the mammalian TRPM7, a magnesium channel required during embryonic development
The transient receptor potential ion channel subfamily M, member 7 (TRPM7), is a ubiquitously
expressed protein that is required for mouse embryonic development. TRPM7 contains …
expressed protein that is required for mouse embryonic development. TRPM7 contains …
Optimization of multiplexed bead-based cytokine immunoassays for rat serum and brain tissue
RE Hulse, PE Kunkler, JP Fedynyshyn… - Journal of neuroscience …, 2004 - Elsevier
The ability to simultaneously quantify multiple signaling molecule protein levels from
microscopic neural tissue samples would be of great benefit to deciphering how they affect brain …
microscopic neural tissue samples would be of great benefit to deciphering how they affect brain …
Astrocytic clasmatodendrosis in hippocampal organ culture
RE Hulse, J Winterfield, PE Kunkler, RP Kraig - Glia, 2001 - Wiley Online Library
Mechanisms by which astrocytes are irreversibly injured from ischemic brain injury remain
incompletely defined. More than 90 years ago Alzheimer showed that astrocytes lose their …
incompletely defined. More than 90 years ago Alzheimer showed that astrocytes lose their …
Biomolecular DNP‐Supported NMR Spectroscopy using Site‐Directed Spin Labeling
…, EJ Koers, C Sauvée, RE Hulse… - … A European Journal, 2015 - Wiley Online Library
Dynamic nuclear polarization (DNP) has been shown to greatly enhance spectroscopic
sensitivity, creating novel opportunities for NMR studies on complex and large molecular …
sensitivity, creating novel opportunities for NMR studies on complex and large molecular …
Optical current source density analysis in hippocampal organotypic culture shows that spreading depression occurs with uniquely reversing currents
PE Kunkler, RE Hulse, MW Schmitt… - Journal of …, 2005 - Soc Neuroscience
Spreading depression (SD) involves current flow through principal neurons, but the pattern
of current flow over the expanse of susceptible tissues or individual principal neurons …
of current flow over the expanse of susceptible tissues or individual principal neurons …
Cryo-EM structure of the polycystin 2-l1 ion channel
10.7554/eLife.36931.001 We report the near atomic resolution (3.3 Å) of the human polycystic
kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 …
kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 …
Multiplexed cytokine protein expression profiles from spreading depression in hippocampal organotypic cultures
PE Kunkler, RE Hulse, RP Kraig - Journal of Cerebral Blood …, 2004 - journals.sagepub.com
Cytokines are involved in ischemic tolerance, including that triggered by spreading depression
(SD), yet their roles in neuroprotection remain incompletely defined. The latter may stem …
(SD), yet their roles in neuroprotection remain incompletely defined. The latter may stem …