A central question in Alzheimer's disease concerns the mechanism by which β-amyloid
contributes to neuropathology, and in particular whether intracellular versus extracellular β-…

Multiple lines of evidence implicate β-amyloid (Aβ) in the pathogenesis of Alzheimer's disease
(AD), but the mechanisms whereby Aβ is involved remain unclear. Addition of Aβ to the …

Synaptic dysfunction is increasingly viewed as an early manifestation of Alzheimer's disease
(AD), but the cellular mechanism by which β-amyloid (Aβ) may affect synapses remains …

The aberrant accumulation of aggregated β-amyloid peptides (Aβ) as plaques is a hallmark
of Alzheimer’s disease (AD) neuropathology and reduction of Aβ has become a leading …

Plaques are a defining neuropathological hallmark of Alzheimer's disease (AD) and the major
constituent of plaques, the β-amyloid peptide (Aβ), is considered to play an important role …

Increasing evidence links intraneuronal β-amyloid (Aβ 42 ) accumulation with the pathogenesis
of Alzheimer’s disease (AD). In Aβ precursor protein (APP) mutant transgenic mice and …

Amyloid plaques and neurofibrillary tangles (NFTs) in the brain are the neuropathological
hallmarks of Alzheimer's disease (AD). Amyloid plaques are composed of β‐amyloid peptides (…

A growing body of evidence suggests a relationship between oxidative stress and β‐amyloid
(Aβ) peptide accumulation, a hallmark in the pathogenesis of Alzheimer's disease (AD). …

© 2012 The Japan Society of Histochemistry and Salivary gland tumors are relatively uncommon
and there exists a considerable diagnostic difficulty owing to their diverse histological …

Although β-amyloid (Aβ) plaques and tau neurofibrillary tangles are hallmarks of Alzheimer's
disease (AD) neuropathology, loss of synapses is considered the best correlate of cognitive …