Huntington's disease (HD) is a fatal, dominant neurodegenerative disease caused by a
polyglutamine repeat expansion in exon 1 of the HD gene, which encodes the huntingtin protein. …

RNAi interference (RNAi) is a powerful gene silencing technology that has immense
potential for treating a vast array of human ailments, for which suppressing disease-associated …

RNA interference (RNAi) provides a promising therapeutic approach to human diseases.
However, data from recent reports demonstrate that short-hairpin RNAs (shRNAs) may cause …

Huntington's disease (HD) is a fatal neurodegenerative disease caused by mutant huntingtin
(htt) protein, and there are currently no effective treatments. Recently, we and others …

To date, a therapy for Huntington's disease (HD), a genetic, neurodegenerative disorder,
remains elusive. HD is characterized by cell loss in the basal ganglia, with particular damage to …

The orchestration of brain function requires complex gene regulatory networks that are
modulated, in part, by microRNAs (miRNAs). These noncoding RNAs associate with argonaute (…

Alzheimer's disease is a major cause of dementia for which treatments remain unsatisfactory.
Cyclin-dependent kinase 5 (CDK5) is a relevant kinase that has been hypothesized to …

Mitochondria are composed of many small proteins that control protein synthesis, complex
assembly, metabolism, and ion and reactive oxygen species (ROS) handling. We show that a …

Myocardial mitochondrial Ca 2+ entry enables physiological stress responses but in excess
promotes injury and death. However, tissue-specific in vivo systems for testing the role of …

RNA interference (RNAi) is a cellular process regulating gene expression and participating
in innate defense in many organisms. RNAi has also been utilized as a tool to query gene …